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Title | PMID | PMCID | Public Release Type | Publication Year | DOI | Study Acronym | Study Network | Request ID(s) | Public Release Origin |
|---|---|---|---|---|---|---|---|---|---|
| A ranked-based approach to evaluate a surrogate marker in a small sample size setting | 38386359 | PMC10883071 | Journal | 2024 | 10.1093/biomtc/ujad035 | TONIC | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 23684 | Secondary Research |
| Alanine Aminotransferase as a Monitoring Biomarker in Children with Nonalcoholic Fatty Liver Disease: A Secondary Analysis Using TONIC Trial Data. | 29799476 | PMC6025615 | Journal | 2018 | 10.3390/children5060064 | TONIC | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 21114 | Secondary Research |
| Among Patients with Nonalcoholic Fatty Liver Disease, Modest Alcohol Use is Associated with Less Improvement in Histologic Steatosis and Steatohepatitis | 29378307 | PMC6098737 | Journal | 2018 | 10.1016/j.cgh.2018.01.026 | FLINT | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 21513, 21515 | Secondary Research |
| Association Between Polypharmacy, Patient Reported Symptoms, and Quality of Life among Nonalcoholic Fatty Liver Disease Patients in the United States. | Journal | 2022 | 10.1007/s40267-022-00957-z | NAFLD Pediatric, PIVENS, NAFLD Adult, TONIC | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 23211 | Secondary Research | ||
| Association of changes in histological severity of non-alcoholic steatohepatitis and changes in patient-reported quality of life | 35903833 | PMC9512481 | Journal | 2022 | 10.1002/hep4.2044 | PIVENS, FLINT | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 23138 | Secondary Research |
| Changes in Serum Cytokeratin 18 Levels Significantly Predict Changes in Liver Histology in Adults With Nonalcoholic Steatohepatitis: Results From the Pivens Trial | Journal | 2013 | PIVENS | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | Contributing Study | ||||
| Changes in abdominal adipose tissue depots assessed by MRI correlate with hepatic histologic improvement in non-alcoholic steatohepatitis. | 36368598 | PMC9852022 | Journal | 2023 | 10.1016/j.jhep.2022.10.027 | FLINT | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 21852 | Secondary Research |
| Changes in adipose tissue insulin resistance correlate with changes in ALT and lobular inflammation in children enrolled in the TONIC trial | Journal | 2011 | TONIC | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | Contributing Study | ||||
| Clinical Research Network launches TONIC trial for treatment of nonalcoholic fatty liver disease in children. | 16456401 | Journal | 2006 | 10.1097/01.mpg.0000189332.77644.1f | TONIC | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | Contributing Study | ||
| Clinically Actionable Hypercholesterolemia and Hypertriglyceridemia in Children with Nonalcoholic Fatty Liver Disease | 29661561 | PMC6019181 | Journal | 2018 | 10.1016/j.jpeds.2018.02.038 | TONIC | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 21114 | Secondary Research |
| Defining the serum proteomic signature of hepatic steatosis, inflammation, ballooning and fibrosis in non-alcoholic fatty liver disease. | 36528237 | PMC10165617 | Journal | 2023 | 10.1016/j.jhep.2022.11.029 | NAFLD Pediatric | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 22511, 23382 | Secondary Research |
| Development of a novel machine learning model to predict presence of nonalcoholic steatohepatitis. | 33684933 | PMC8200272 | Journal | 2021 | 10.1093/jamia/ocab003 | NAFLD Adult | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 21817 | Secondary Research |
| Effect of Polypharmacy on Health-related Quality of Life in Pediatric Patients with Nonalcoholic Fatty Liver Disease in the United States. | Journal | 2024 | TONIC, NAFLD Adult, NAFLD Pediatric, PIVENS | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 23211 | Secondary Research | |||
| Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial. | 21521847 | PMC3110082 | Journal | 2011 | 10.1001/jama.2011.520 | TONIC | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | Contributing Study | |
| Elevated Serum Ferritin Values Above the Upper Limit of Normal Are Associated With Laboratory and Histologic Evidence of Increased NASH Severity, but Not the Presence of Diabetes or Metabolic Syndrome Among Patients in the NASH CRN | Journal | 2011 | PIVENS | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | Contributing Study | ||||
| Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. | 25468160 | PMC4447192 | Journal | 2015 | 10.1016/S0140-6736(14)61933-4 | FLINT | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | Contributing Study | |
| Genetic Variants Associated with Obesity and Insulin Resistance in Hispanic Boys with Nonalcoholic Fatty Liver Disease | 29470286 | PMC5916321 | Journal | 2018 | 10.1097/MPG.0000000000001926 | NAFLD GOALS | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 21293 | Secondary Research |
| Genetic polymorphism of cytochrome P450 4F2, vitamin E level and histological response in adults and children with nonalcoholic fatty liver disease who participated in PIVENS and TONIC clinical trials. | 24759732 | PMC3997354 | Journal | 2014 | 10.1371/journal.pone.0095366 | PIVENS, TONIC | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | Contributing Study | |
| Genome Wide Associations Related to Hepatic Histology in Nonalcoholic Fatty Liver Disease in Hispanic Boys | 28918882 | PMC5690841 | Journal | 2017 | 10.1016/j.jpeds.2017.08.004 | NAFLD GOALS | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 21293 | Secondary Research |
| Glycogenosis is common in nonalcoholic fatty liver disease and is independently associated with ballooning, but lower steatosis and lower fibrosis | 33354866 | PMC8052274 | Journal | 2021 | 10.1111/liv.14773 | NAFLD Database | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 22585, 22613 | Secondary Research |
| HSD17B13 is a Hepatic Retinol Dehydrogenase Associated with Histological Features of Non-Alcoholic Fatty Liver Disease | 30415504 | PMC6438737 | Journal | 2018 | 10.1002/hep.30350 | PIVENS | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 20860 | Secondary Research |
| Hepatic Fat in Participants With and Without Incident Diabetes in the Diabetes Prevention Program Outcome Study | 33705543 | PMC8530730 | Journal | 2021 | 10.1210/clinem/dgab160 | NAFLD Adult | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 20960 | Secondary Research |
| Hepatic R2* is more strongly associated with proton density fat fraction than histologic liver iron scores in patients with nonalcoholic fatty liver disease | 30318834 | PMC6449180 | Journal | 2019 | 10.1002/jmri.26312 | FLINT | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 21852 | Secondary Research |
| Histologic Predictors of Improvement in Fibrosis in NASH: Results from the Clinical Research Network PIVENS Trial | Journal | 2012 | PIVENS | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | Contributing Study | ||||
| Histologic findings of advanced fibrosis and cirrhosis in patients with NAFLD who have normal aminotransferase levels | 31517638 | PMC6800246 | Journal | 2019 | 10.14309/ajg.0000000000000388 | NAFLD Database | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 22585 | Secondary Research |
| Impact of the association between PNPLA3 genetic variation and dietary intake on the risk for significant fibrosis in patients with NAFLD | 33306506 | PMC8087619 | Journal | 2021 | 10.14309/ajg.0000000000001072 | NAFLD Database | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 22585, 22613 | Secondary Research |
| Improvements in Histologic Features and Diagnosis Associated With Improvement in Fibrosis in Nonalcoholic Steatohepatitis: Results From the Nonalcoholic Steatohepatitis Clinical Research Network Treatment Trials. | 30549292 | PMC6570584 | Journal | 2019 | 10.1002/hep.30418 | FLINT | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 21513 | Secondary Research |
| In Children With Nonalcoholic Fatty Liver Disease, Cysteamine Bitartrate Delayed Release Improves Liver Enzymes but Does Not Reduce Disease Activity Scores. | 27569726 | PMC5124386 | Journal | 2016 | 10.1053/j.gastro.2016.08.027 | CyNCh | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | Contributing Study | |
| Low Testosterone Is Associated With Nonalcoholic Steatohepatitis and Fibrosis Severity in Men. | 31812658 | PMC7272262 | Journal | 2021 | 10.1016/j.cgh.2019.11.053 | NAFLD Pediatric | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 22511 | Secondary Research |
| Low and High Birth Weights are Risk Factors for Nonalcoholic Fatty Liver Disease in Children | 28366357 | PMC5533631 | Journal | 2017 | 10.1016/j.jpeds.2017.03.007 | NAFLD Adult | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 21513 | Secondary Research |
| Magnetic Resonance Elastography Shear Wave Velocity Correlates with Liver Fibrosis and Hepatic Venous Pressure Gradient in Adults with Advanced Liver Disease | 28480218 | PMC5396439 | Journal | 2017 | 10.1155/2017/2067479 | NAFLD Adult | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 21460 | Secondary Research |
| Metabolome × Microbiome Changes Associated with a Diet-Induced Reduction in Hepatic Fat among Adolescent Boys. | 36984841 | PMC10053986 | Journal | 2023 | 10.3390/metabo13030401 | NAFLD Pediatric | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 22449 | Secondary Research |
| Metabolomic Profiling to Define Predictors of Response to Vitamin E for Non- Alcoholic Steatohepatitis (NASH) | Journal | 2011 | PIVENS | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | Contributing Study | ||||
| Microbiome Signatures Associated With Steatohepatitis and Moderate to Severe Fibrosis in Children With Nonalcoholic Fatty Liver Disease. | 31255652 | PMC6756995 | Journal | 2019 | 10.1053/j.gastro.2019.06.028 | NAFLD Pediatric | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 22511 | Secondary Research |
| NASHmap: clinical utility of a machine learning model to identify patients at risk of NASH in real-world settings. | 37019931 | PMC10076319 | Journal | 2023 | 10.1038/s41598-023-32551-2 | NAFLD Adult | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 21817 | Secondary Research |
| Nonalcoholic fatty liver disease risk and histologic severity are associated with genetic polymorphisms in children. | 35560106 | PMC9653518 | Journal | 2023 | 10.1002/hep.32570 | NAFLD Pediatric | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 22511, 23382 | Secondary Research |
| Pioglitazone versus vitamin E versus placebo for the treatment of non-diabetic patients with non-alcoholic steatohepatitis: PIVENS trial design. | 18804555 | PMC2929909 | Journal | 2009 | 10.1016/j.cct.2008.09.003 | PIVENS | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | Contributing Study | |
| Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. | 20427778 | PMC2928471 | Journal | 2010 | 10.1056/NEJMoa0907929 | PIVENS | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | Contributing Study | |
| Prospective Study of Outcomes in Adults with Nonalcoholic Fatty Liver Disease | 34670043 | PMC8881985 | Journal | 2022 | 10.1056/NEJMoa2029349 | FLINT | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 21167, 21177, 21318, 21513, 21515, 21668, 21721, 22585, 22613, 22939, 22935, 22936, 22937, 22938, 23122 | Secondary Research |
| Randomized placebo-controlled trial of losartan for pediatric NAFLD. | 35133671 | PMC9288975 | Journal | 2022 | 10.1002/hep.32403 | NAFLD Pediatric | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 22449 | Secondary Research |
| Response to Vitamin E for Non-Alcoholic Steatohepatitis (NASH): What Is the Mechanism? | Journal | 2013 | PIVENS | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | Contributing Study | ||||
| Rheological Determinants for Simultaneous Staging of Hepatic Fibrosis and Inflammation in Patients with Chronic Liver Disease | 30059174 | PMC6141320 | Journal | 2018 | 10.1002/nbm.3956 | NAFLD Adult | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 21460 | Secondary Research |
| Shorter leukocyte telomere length protects against NAFLD progression in children. | 37012261 | PMC10070244 | Journal | 2023 | 10.1038/s41598-023-31149-y | TONIC | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 22690 | Secondary Research |
| Testosterone is Associated With Nonalcoholic Steatohepatitis (NASH) and Fibrosis in Pre-Menopausal Women With NAFLD | 33010412 | PMC8175071 | Journal | 2020 | 10.1016/j.cgh.2020.09.045 | FLINT | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 21167, 21177, 21318, 21513, 21515, 21668, 21721, 22585, 22613 | Secondary Research |
| The Effect of Polypharmacy on Quality of Life in Adult Patients with Nonalcoholic Fatty Liver Disease in the United States. | 35064417 | Journal | 2022 | 10.1007/s11136-022-03090-6 | NAFLD Adult, NAFLD Pediatric, TONIC, PIVENS | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 23211 | Secondary Research | |
| The Nimble Stage 1 Study Validates Diagnostic Circulating Biomarkers for Nonalcoholic Steatohepatitis | 36711803 | PMC9882658 | Journal | 2023 | 10.21203/rs.3.rs-2492725/v1 | FLINT | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 21167, 21177, 21318, 21668, 21721, 22939, 22935, 22936, 22937, 22938, 23122, 23382 | Secondary Research |
| The Protection Conferred by HSD17B13 rs72613567 Polymorphism on Risk of Steatohepatitis and Fibrosis May Be Limited to Selected Subgroups of Patients With NAFLD | 34506332 | PMC8437218 | Journal | 2021 | 10.14309/ctg.0000000000000400 | NAFLD Database | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 22585, 22613 | Secondary Research |
| The nonalcoholic steatohepatitis extended hepatocyte ballooning score: histologic classification and clinical significance | 36724127 | PMC9894357 | Journal | 2023 | 10.1097/HC9.0000000000000033 | NAFLD Database | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 22585, 22613 | Secondary Research |
| The roles of type 2 diabetes and obesity in disease activity and progression of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis | 37933187 | Journal | 2024 | 10.1080/03007995.2023.2279676 | CyNCh, FLINT, NAFLD Pediatric, PIVENS, NAFLD Adult, TONIC | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | 23059 | Secondary Research | |
| Treatment of nonalcoholic fatty liver disease in children: TONIC trial design. | 19761871 | PMC2936451 | Journal | 2010 | 10.1016/j.cct.2009.09.001 | TONIC | Nonalcoholic Steatohepatitis Clinical Research Network (NASH) | Contributing Study |