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Vitamin D Deficiency Is Associated With Increased Risk of Non-alcoholic Steatohepatitis in Adults With Non-alcoholic Fatty Liver Disease: Possible Role for MAPK and NF-κB?

Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-Stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV. Vitamin D Deficiency Is Associated With Increased Risk of Non-alcoholic Steatohepatitis in Adults With Non-alcoholic Fatty Liver Disease: Possible Role for MAPK and NF-κB? Am J Gastroenterol 2016 Jun;111(6):852-63. Epub 2016 Mar 22.

PubMed ID: 27002799
Public Release Type: Journal
Publication Year: 2016
Affiliation: Liver Care Network, Swedish Medical Center, Seattle, Washington, USA.
DOI: https://doi.org/10.1038/ajg.2016.51
Authors: Yates KP, Aouizerat B, Morgan-Stevenson V, Whalen E, Kowdley KV, Hoofnagle A, Gersuk V, Mason M, Yeh MM, Nelson JE, Roth CL, Wilson LA
Studies: Nonalcoholic Steatohepatitis Clinical Research Network

Abstract

The objective of this study was to determine the relationship of serum vitamin D deficiency (VDD) to histologic features of non-alcoholic fatty liver disease (NAFLD), and associated demographic, clinical, laboratory, and transcriptomic data in the well-characterized Non-alcoholic Steatohepatitis Clinical Research Network (NASH CRN) cohort.

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Vitamin D Deficiency Is Associated With Increased Risk of Non-alcoholic Steatohepatitis in Adults With Non-alcoholic Fatty Liver Disease: Possible Role for MAPK and NF-κB?

Abstract