NIDDK Central Repository - Resources for Research (NIDDK-CR R4R) facilitates sharing of data, biospecimens, and other resources generated from studies supported by NIDDK and within NIDDK’s mission by making these resources available for request to the broader scientific and research community.
* Note: Studies may fall within more than one research area.
February 28, 2024
In September 2023, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Central Repository announced the Data Centric Challenge aimed at enhancing NIDDK datasets for future artificial intelligence (AI) applications. Challenge participants were tasked to generate an AI-ready dataset that can be used for future data challenges and produce methods to enhance the AI-readiness of NIDDK data. Participation in the Challenge was tiered (i.e., beginner-level and intermediate/advanced-level) and utilized data from two longitudinal studies focused on type 1 diabetes (TEDDY and TrialNet). NIDDK is excited to announce ICF Inc. and FI Consulting as the Data Centric Challenge winners. Visit Challenge.gov to read more about the winning solutions: https://www.challenge.gov/?challenge=niddk-central-repository-data-centric-challenge&tab=winners
June 1, 2023
Join us for a two-day virtual workshop on September 19th and 20th, from 10 a.m. to 3:00 p.m. (Eastern Time), focused on promoting secondary research to accelerate medical breakthroughs and foster innovation. Renowned guest speakers, engaging panel discussions, and informative lightning talks will shed light on the history and valuable resources of NIDDK-CR as we commemorate its 20th anniversary. Plus, don’t miss the introduction of our new analytics workspace and the launch of our data-centric challenge to enhance research capabilities. Mark your calendars now and be part of this extraordinary event! Register here: https://www.niddk.nih.gov/news/meetings-workshops/2023/central-repository-20th-anniversary-workshop
April 7, 2023
DOIs are now available for every NIDDK-CR R4R study! DOIs increase resource visibility and accessibility and enable appropriate credit citation and interoperability. Researchers are encouraged to use them when making public releases using NIDDK-CR R4R resources. A study’s DOI can be found at the top of the study’s overview page along with citation guidance. Additionally, a data availability statement, with data package version and DOI, is available to requestors who are submitting publications.
April 7, 2023
As of January 25, 2023, the NIH Policy for Data Management and Sharing (DMS) is in effect. All research that is funded in whole or in part by NIH is required to submit a DMS plan outlining how scientific data and accompanying metadata will be managed and shared. NIH DMS plans should address the elements described in the Supplemental Information to the NIH DMS Policy. NIH has provided a DMS plan format on the Writing a Data Management and Sharing Plan page on the NIH Scientific Data Sharing website. NIDDK is offering Institute-specific guidance for Writing a DMS Plan and provides NIDDK DMS Tools and Examples.
November 30, 2022
This revamped, streamlined process for requesting biospecimens incorporates user feedback to better facilitate access to biospecimens. Certain requests will still require an X01 Resource Access Award; however, many will need only an administrative review or will leverage existing grant applications peer review if one was submitted. The new request process is designed to share NIDDK-CR resources with more researchers faster and easier to continue fostering innovative research. Researchers can visit the Material Counts page to explore the available resources and start a request.
October 6, 2022
Vivli and the National Institute of Diabetes and Digestive and Kidney Disease (NIDDK), part of the National Institutes of Health (NIH), will be working together to broaden exposure and strengthen NIDDK data ecosystem. As part of Vivli’s award to serve as one of six generalist repositories that will work with the NIH Office of Data Science Strategy under its Generalist Repository Ecosystem Initiative (GREI), NIDDK will include NIDDK Central Repository (NIDDK-CR) resources in the Vivli global clinical research data sharing platform. NIDDK-CR’s resources inclusion within Vivli as part of GREI improves discoverability and reuse of NIDDK-CR hosted resources making data more Findable, Accessible, Interoperable, and Reusable (FAIR), increases the scientific value by providing additional opportunities to the NIDDK scientific community, and maximizes the contributions of research participants.
To learn more: contact Dr. Rebecca Rodriguez or visit the Vivli member page.
November 17, 2021
The NIDDK Central Repository (CR) plays a crucial role in making data Findable, Accessible, Interoperable, and Reusable (FAIR). To enhance FAIRness of studies in the Repository, NIDDK and Booz Allen Hamilton, the current Data Repository contractor, have piloted a natural language processing (NLP) pipeline project for harmonizing study variables with NIH CDEs and for identifying potential new CDEs from dataset variables mapped to ontology concepts. Initial results show highly specific mapping of variables to CDEs as well as successful identification of relevant concepts for new CDEs. The pipeline can be refined and applied to other studies to potentially improve FAIRness of the NIDDK CR.
Contact Dr. Rebecca Rodriguez with any questions.
June 5, 2023
The goal of this Notice of Special Interest (NOSI) is to provide support through administrative supplements collaborations to improve interoperability/re-use for NIDDK supported T2D data sets and related resources such as repositories and knowledgebases. NIDDK mandates its funded projects to comply with the FAIR principles, i.e., making all data sets and related resources Findable, Accessible, Interoperable and Reusable. While Findability and Accessibility are usually achieved, many projects face unexpected challenges in making their data sets and related resources Interoperable with that from other programs and projects, which consequently also affect the Reusability. This also poses obstacles in the reuse of data and tools that capitalize on the latest data science advancements such as those in AI/ML, where the greatest potential lies in automated integration of large multi-modal data types for discovery and novel hypothesis generation. For additional details on the opportunity, see the NIH grant page. Submissions are due July 11, 2023.
March 19, 2022
This funding opportunity announcement invites applications from multidisciplinary teams to perform secondary data analysis, using existing datasets from two or more multi-site clinical research projects, including clinical trials, natural history studies, and/or comparative effectiveness research. Secondary analyses should address scientific and / or clinical hypotheses that can advance the understanding or care of neurological disorders and conditions within the NINDS mission. In this phased award funding mechanism, applications are required to systematically and comprehensively perform cross-project data harmonization and curation, assessed using go/no-go data-quality metrics, prior to performing secondary analyses of existing clinical data. Consistent with the FAIR (findable, accessible, interoperable and reusable) data principles, this funding opportunity expects open-source cataloging of the processes and tools used for harmonization, curation, and analysis, as well as controlled access to the curated datasets. For additional details on the opportunity, see the NIH grant page.
October 21, 2020
NIDDK has posted an opportunity for those using secondary data in new analyses. The eligible data includes that which can be requested via the repository website. For additional details on the opportunity, see the NIH grant page.
February 8, 2024
A new study, Immune Regulation and Costimulation in Natural History of Chronic Hepatitis B (HBRN Immunology Cohort), has been posted to the NIDDK Central Repository. Data from this study are now available for request. The Immune Regulation and Costimulation in …
February 6, 2024
A new study, Immune Regulation and Costimulation in Natural History and Therapeutic Outcome of Chronic Hepatitis B (HBRN Immunology Treatment), has been posted to the NIDDK Central Repository. Data from this study are now available for request. Immune Regulation and …
January 5, 2024
A new study, Nonalcoholic Fatty Liver Disease Adult Database 2 (NAFLD Adult Database 2), has been posted to the NIDDK Central Repository. Data and biospecimens from this study are now available for request. The Nonalcoholic Steatohepatitis Clinical Research Network (NASH …