PubMed ID:
26390278
Public Release Type:
Journal
Publication Year: 2015
Affiliation: University of Michigan.
DOI:
https://doi.org/10.1002/hep.28110
Authors:
Fontana RJ,
Lisker-Melman M,
Chung RT,
Ghany MG,
Lee WM,
Khalili M,
Kleiner D,
Sterling RK,
Belle S,
Brunt EM,
Carithers RC,
Chang KM,
Cloonan Y,
Cooper SL,
Di Bisceglie AM,
Do S,
Evon D,
Feld J,
Fried MW,
Han SH,
HBRN,
Heathcote J,
Janssen HL,
Juan J,
Kim WR,
Kowdley KV,
Lau D,
Liang TJ,
Lok AS,
Lombardero M,
Park JJ,
Patel K,
Perrillo R,
Roberts LR,
Sanyal A,
Shuhart M,
Smith CI,
Terrault NA,
Tran TT,
Tsai N,
Wahed A,
Wang CC,
Wong DK,
Yim C
Studies:
Hepatitis B Research Network
Diabetes is associated with liver disease progression and increased hepatocellular carcinoma risk, but factors associated with diabetes in patients with chronic hepatitis B virus (HBV) infection in North America are unknown. We aimed to determine factors predictive of diabetes and impaired fasting glucose (IFG) in a large HBV-infected multiethnic cohort. Adults with chronic HBV not receiving antiviral therapy were enrolled from 21 centers in North America. Diabetes was defined by history/medication use or fasting glucose≥126 mg/dL and IFG as fasting glucose 100-125 mg/dL. Of 882 patients included, 47.2% were female, 71.3% Asian, 83.7% foreign born, median age was 44 years, and median body mass index BMI 24.3 kg/m2. In this cohort, 26.0% were hepatitis B envelope antigen (HBeAg) positive, 43.9% had HBV DNA≥20,000 IU/mL, and 26.7% alanine aminotransferase (ALT)≥2× upper limit of normal (≥40 U/L women, ≥60 U/L men). Overall, 12.5% had diabetes and 7.8% IFG. The combined prevalence of diabetes or IFG was highest among blacks (36.7%) and those either born in the United States/Canada or foreign born with migration>20 years ago (25.5%). Obesity (odds ratio [OR]: 2.13), hyperlipidemia (OR, 4.13), hypertension (OR, 3.67), high ALT level (OR, 1.86), and family history of diabetes (OR, 3.43) were associated with diabetes. Factors associated with IFG were obesity (OR, 4.13) and hypertension (OR, 3.27), but also HBeAg positivity (OR, 0.39). Recent migration was negatively associated with diabetes among non-Asians (OR, 0.30).