PubMed ID:
24934506
Public Release Type:
Journal
Publication Year: 2014
Affiliation: Program in Genetics and Genomic Biology, Hospital for Sick Children, 686 Bay Street, Room 12.9830, Toronto, ON, M5G 0A4, Canada.
DOI:
https://doi.org/10.1007/s00125-014-3286-9
Authors:
Alizadeh BZ,
Atzmon G,
Barzilai N,
Ben-Avraham D,
Boezen HM,
Braffett BH,
Bruinenberg M,
Cleary PA,
Crandall JP,
DCCT/EDIC Research Group,
de Boer RA,
Eny KM,
Franke L,
Graaff R,
Hillege HL,
Hosseini SM,
Howard K,
Klein BE,
Klein R,
Lee KE,
LifeLines Cohort Study Group,
Lutgers HL,
Lyons TJ,
Maynard J,
Milman S,
Monnier VM,
Navis G,
Orchard TJ,
Ormel J,
Paterson AD,
Postma DS,
Rosmalen JG,
Sell DR,
Slaets JP,
Snieder H,
Snieder H,
Stolk RP,
van der Harst P,
van der Harst P,
van der Klauw MM,
van der Klauw MM,
van Vliet-Ostaptchouk JV,
Wijmenga C,
Wolffenbuttel BH,
Wolffenbuttel BH
Studies:
Diabetes Control and Complications Trial
Skin fluorescence (SF) is a non-invasive marker of AGEs and is associated with the long-term complications of diabetes. SF increases with age and is also greater among individuals with diabetes. A familial correlation of SF suggests that genetics may play a role. We therefore performed parallel genome-wide association studies of SF in two cohorts.