PubMed ID:
24828609
Public Release Type:
Journal
Publication Year: 2014
Affiliation: Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, 34th & Civic Center Boulevard, Philadelphia, PA, 19104, USA, hartunge@email.chop.edu.
DOI:
https://doi.org/10.1007/s00467-014-2816-5
Authors:
Dell KM,
Furth SL,
Gerson AC,
Guay-Woodford LM,
Hartung EA,
Hooper SR,
Lande MB,
Matheson M,
Warady BA
Studies:
The Chronic Kidney Disease in Children Cohort Study
Autosomal recessive polycystic kidney disease (ARPKD) is an inherited disorder characterized by enlarged, cystic kidneys with progressive chronic kidney disease (CKD), systemic hypertension, and congenital hepatic fibrosis. Children with ARPKD can have early onset CKD and severe hypertension, both of which are known to have adverse neurocognitive effects. The objectives of this study were (1) to determine whether ARPKD patients have greater neurocognitive deficits compared to that of children with other causes of CKD, and (2) to examine the relative prevalence of hypertension in ARPKD, a known risk factor for neurocognitive dysfunction.