PubMed ID:
24488505
Public Release Type:
Journal
Publication Year: 2014
Affiliation: Pediatric Nephrology, Dialysis and Transplantation, Phoenix Children's Hospital, 1919 E Thomas Road, Phoenix, AZ, 85016, USA, gbarletta@phoenixchildrens.com.
DOI:
https://doi.org/10.1007/s00467-013-2737-8
Authors:
Barletta GM,
Cox C,
Flynn J,
Friedman LA,
Furth S,
Mitsnefes M,
Ng D,
Poffenbarger T,
Samuels J,
Warady B
Studies:
The Chronic Kidney Disease in Children Cohort Study
Autonomic nervous system dysfunction and sympathetic nervous system over-activity play important roles in the development of hypertension associated with chronic kidney disease (CKD). In adults, increased blood pressure variability (BPV) appears to be directly related to sympathetic over-activity with increased risk of end-organ damage and cardiovascular events. Decreased heart rate variability (HRV) has been observed in adults with CKD, and is an independent predictor of mortality.