Public Release Type:
Journal
Publication Year: 2013
Authors:
Athinarayanan SJ,
Bai S,
Chalasani NP,
Cummings OW,
Liu W,
Molleston JP,
Traber MG,
Wei R,
Yates KP
Studies:
Nonalcoholic Steatohepatitis Clinical Research Network
Alpha-tocopherol (Vit E) treatment improved liver histology in children and adults with NAFLD who participated in TONIC and PIVENS clinical trials, but there was significant inter-individual variability in the response to Vit E in these two trials. Cytochrome P450 4F2 (CYP4F2) is the major enzyme that metabolizes Vit E into polar metabolites which are subsequently excreted in urine. Two common variants in the CYP4F2 gene (V433M and W12G) are known to exist and it is possible that such variants may explain the variability in the response to Vit E among individuals participating in NAFLD trials.