PubMed ID:
23562090
Public Release Type:
Journal
Publication Year: 2013
Affiliation: University of Minnesota, Minneapolis, MN, USA.
DOI:
https://doi.org/10.1016/S0140-6736(13)60023-9
Authors:
Knip M,
Liu S,
Abbondondolo M,
Abraham A,
Acosta B,
Adams T,
Adi S,
Ahenkorah B,
AIDA Study Group,
Aide J,
Alford M,
Alies P,
Althaus E,
Amado DM,
Andersen HU,
Anderson M,
Anderson M,
Arazo L,
Arce R,
Arthur J,
Atkinson M,
Atkinson M,
Aufschild J,
Axpe Pascual RM,
Aye T,
Babu S,
Badenhoop K,
Badenhoop K,
Baden L,
Badias F,
Badias F,
Baker B,
Bak JF,
Bak JF,
Bassi M,
Batts E,
Beam C,
Becker D,
Becker D,
Becker DJ,
Beck G,
Benoist C,
Berry B,
Bingley P,
Bjerre-Christensen U,
Blagieva R,
Blaschke C,
Bluestone J,
Blumberg E,
Blum J,
Böehm B,
Böehm B,
Bollepalli S,
Bollyky J,
Boonstra M,
Bosi E,
Boulware D,
Bourcier K,
Bourcier K,
Braun J,
Breen K,
Brillon D,
Brown D,
Buckingham BA,
Buckner J,
Bundy B,
Bundy B,
Bundy B,
Bunk M,
Carrasco L,
Castaño L,
Castaño L,
Cevallos J,
Chan M,
Chase HP,
Cisneros M,
Clare-Salzler M,
Clare-Salzler M,
Cole G,
Colman P,
Cook R,
Copemen B,
Cowie C,
Cowie C,
Cuthbertson D,
Cuthbertson D,
Dahlquist G,
Davis R,
de Koning E,
de Koning E,
Delallo K,
del Pino Alberiche M,
Diez A,
Dijk M,
DiMeglio L,
DiMeglio L,
DiMeglio LA,
Donath M,
Donath MY,
Dove A,
Eberhard C,
Eisel LA,
Eisenbarth GS,
Eisenbarth GS,
Elnyczky B,
Esrey T,
Evans-Molina C,
Fathman CG,
Feldman L,
Ferguson J,
Fernandez S,
Foght H,
Ford J,
Ford L,
Foulkes M,
Fradkin J,
Frandsen M,
Frederiksen A,
Freeman D,
Gale EA,
Gallagher MP,
García Núñez MA,
Gaztambide S,
Giannopoulou E,
Gibson C,
Ginem J,
Gitelman S,
Gitelman SE,
Gitelman SE,
Goland R,
Goland R,
Goland R,
González Mielgo J,
Gottlieb P,
Granger M,
Grave G,
Greenbaum C,
Greenbaum C,
Greenbaum C,
Greenbaum CJ,
Greenbaum CJ,
Greenbaum CJ,
Greenberg E,
Green M,
Gubitosi-Klug R,
Guglielmi C,
Guillette H,
Gurtunca N,
Haller M,
Hamilton C,
Hammond M,
Harrison L,
Hays B,
Hefty D,
Heidkamp P,
Hemmingsen B,
Henry M,
Herbst M,
Herder C,
Hering B,
Hering B,
Hernández Garcia M,
Herold K,
Herold KC,
Herold KC,
Hilderman N,
Holm Pedersen L,
Hornemann T,
Hufferd R,
Hutchins M,
Insel R,
Jordan S,
Kahl S,
Kaufman FR,
Kenyon NS,
Kieffer M,
Kleijwegt F,
Klein J,
Kovalakovska R,
Krause-Steinrauf H,
Krischer JP,
Krischer JP,
Krischer JP,
Krischer JP,
Krischer JP,
Krog D,
Kuhns K,
Kwong C,
Lachin JM,
Lachin JM,
Laffel L,
Law P,
Lernmark A,
Lervang HH,
Lervang HH,
Leschek E,
Leschek E,
Leschek E,
Leschyshyn J,
Leth C,
Libman I,
Linton C,
Lloyd J,
Lo B,
Loechelt B,
Mahon J,
Malozowski S,
Mancini D,
Mandrup-Poulsen T,
Mandrup-Poulsen T,
Marcovina S,
Marks J,
Marks JB,
Marks JB,
Marrero D,
Martin L,
Matheson D,
Matheson D,
Mauricio D,
Mauricio D,
Mauricio D,
McCulloch-Olson M,
Merger S,
Meyer G,
Mirfakhraee S,
Mitchell H,
Moran A,
Moran A,
Moran A,
Moran A,
Muller S,
Naji A,
Nallamshetty L,
Nanto-Salonen K,
Nathan B,
Nepom G,
Nerup J,
Niebling H,
Nielsen JB,
Nóvoa J,
Nowotny B,
Núria Garcia S,
O'Donnell R,
Onori N,
Orban T,
Orchard T,
Palmer JP,
Palmer JP,
Parkman R,
Parrimon Y,
Paulus K,
Peakman M,
Peakman M,
Peakman M,
Peereboom I,
Perrild H,
Perrild H,
Pescovitz M,
Pescovitz M,
Pescovitz M,
Peyman J,
Peyman J,
Pickersgill L,
Pickersgill L,
Pilger J,
Pozzilli P,
Pozzilli P,
Pugliese A,
Pugliese A,
Pugliese A,
Rafkin L,
Rafkin L,
Rafkin L,
Ramey M,
Ramiro J,
Raskin P,
Raskin P,
Raskin P,
Rasmussen MP,
Regenass S,
Ricahrd J,
Ricci MJ,
Ridge J,
Ridge J,
Riley K,
Ritzie AL,
Roberts A,
Rodriguez H,
Roe E,
Roep B,
Roncarolo MG,
Rosenthal SM,
Rosinger S,
Rungby J,
Russell W,
Sadler K,
Sanda S,
Sanda S,
Sanda S,
Sandler M,
Santiago I,
Savage P,
Savage P,
Schatz D,
Schatz D,
Schatz D,
Schloot N,
Schloot N,
Seelig E,
Seiler M,
Shanker L,
Sherwin R,
Sherwin R,
Shor A,
Siegelman M,
Simell O,
Sironi G,
Skyler JS,
Skyler JS,
Skyler JS,
Skyler JS,
Skyler JS,
Smith J,
Smith K,
Soare A,
Sosenko JM,
Soto A,
Spain L,
Spain L,
Spain L,
Spall M,
Sriskandarajah M,
Steffes M,
Steger R,
Street A,
Tarnow L,
Terrell J,
Terry A,
Thomas J,
Thomas S,
Thyde A,
Timper K,
Trast J,
Tridgell D,
Trucco M,
Trucco M,
Tsiatis A,
Type 1 Diabetes TrialNet Canakinumab Study Group,
Valente L,
Vázquez F,
Veatch R,
Vendettuoli H,
von Eckardstein A,
Wägner A,
Wägner AM,
Wagner J,
Wagner J,
Wallace D,
Wallner M,
Walter M,
Webber C,
Weinberg A,
Weinberg A,
Wentworth J,
Wherrett D,
Wherrett DK,
Wherrett DK,
White P,
Wiesenäcker D,
Wilson DM,
Wilson DM,
Wilson DM,
Winter W,
Winter W,
Wootten M,
Xu P,
Young K,
Yu L,
Zafonte SJ,
Zala P,
Ziegler A,
Ziegler AG,
Ziegler AG,
Zinman B
Innate immunity contributes to the pathogenesis of autoimmune diseases, such as type 1 diabetes, but until now no randomised, controlled trials of blockade of the key innate immune mediator interleukin-1 have been done. We aimed to assess whether canakinumab, a human monoclonal anti-interleukin-1 antibody, or anakinra, a human interleukin-1 receptor antagonist, improved β-cell function in recent-onset type 1 diabetes.