Public Release Type:
Journal
Publication Year: 2012
Authors:
Belt PH,
Dodd CN,
Fenchel M,
Kohli R,
Loomba R,
Rosenthal P,
Sanyal AJ,
Xanthakos S,
Yeh MM
Studies:
Nonalcoholic Steatohepatitis Clinical Research Network
A1AT homozygosity and heterozygosity result in lower serum alpha1- antitrypsin (A1AT) levels in the absence of inflammation. A1AT Heterozygosity results in synergistic liver damage with other chronic liver diseases. We aimed to determine whether serum A1AT levels predict stages of fibrosis in nonalcoholic fatty liver disease (NAFLD) using the nonalcoholic steatohepatitis (NASH) Clinical Research Network’s (CRN) Database. We hypothesized that low serum A1AT levels would predispose to more severe NAFLD.