PubMed ID:
21987488
Public Release Type:
Journal
Publication Year: 2012
Affiliation: University of Colorado Denver, Aurora, CO 80045, USA. kiran.bambha@ucdenver.edu
DOI:
https://doi.org/10.1002/hep.24726
Authors:
Hoofnagle JH,
Vuppalanchi R,
Kleiner DE,
Nguyen A,
Chalasani N,
Abdelmalek MF,
Abraham M,
Ackermann S,
Aouizerat B,
Bambha K,
Bambha K,
Bass M,
Bass N,
Bass NM,
Behling C,
Belt P,
Belt P,
Boyett S,
Brancati FL,
Brandt P,
Bringman D,
Brunt EM,
Buie S,
Clark JM,
Collins J,
Colvin R,
Contos MJ,
Cummings OW,
Dasarathy J,
Dasarathy S,
Dasarathy S,
Diehl AM,
Donithan M,
Doo EC,
Durelle J,
Ferrell L,
Ferrell LD,
Fuchs M,
Ghabril M,
Gottfried M,
Green M,
Gu B,
Guy C,
Hameed B,
Hanna M,
Hassanein T,
Hawkins C,
Hollick R,
Isaacson M,
Jin WK,
Jones A,
Kigongo C,
Killenberg P,
Klipsch A,
Kowdley KV,
Kwan S,
Lavine JE,
Liu YC,
Loomba R,
Luketic VA,
Lydecker A,
Mann P,
May KP,
McCullough AJ,
McCullough AJ,
Merriman R,
Miriel L,
Mooney J,
Morgan A,
Morris A,
Nelson J,
Neuschwander-Tetri BA,
Noble K,
Nonalcoholic Steatohepatitis Clinical Research Network Research Group,
Pabst M,
Pabst M,
Pagadala M,
Pan YP,
Park J,
Patton H,
Pierce T,
Piercy D,
Puri P,
Ragozzino L,
Robuck PR,
Rogers N,
Rosenthal M,
Sandhu B,
Sanyal AJ,
Sargeant C,
Sargent R,
Shaw C,
Sherker A,
Siegner J,
Sirlin C,
Smith M,
Srivastava S,
Stead A,
Steel T,
Sternberg A,
Stewart S,
Subbarao G,
Tandra S,
Thompson J,
Tonascia J,
Unalp-Arida A,
Ünalp-Arida A,
Van Natta M,
Vaughn I,
Wang C,
White M,
Wilson L,
Wilson LA,
Yates K,
Yeh M,
Yerian L,
Zein C
Studies:
Nonalcoholic Steatohepatitis Clinical Research Network
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder in the United States; however, few data are available about racial and ethnic variation. We investigated relationships between ethnicity, NAFLD severity, metabolic derangements, and sociodemographic characteristics in a well-characterized cohort of adults with biopsy-proven NAFLD. Data were analyzed from 1,026 adults (≥18 years) in the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) from 2004 to 2008, for whom liver histology data were available within 6 months of enrollment. Associations between ethnicity (i.e., Latino versus non-Latino white) and NAFLD severity (i.e., NASH versus non-NASH histology and mild versus advanced fibrosis) were explored with multiple logistic regression analysis. We also investigated effect modification of ethnicity on metabolic derangements for NAFLD severity. Within the NASH CRN, 77% (N = 785) were non-Latino white and 12% (N = 118) were Latino. Sixty-one percent (N = 628) had NASH histology and 28% (N = 291) had advanced fibrosis. Latinos with NASH were younger, performed less physical activity, and had higher carbohydrate intake, compared to non-Latino whites with NASH. Gender, diabetes, hypertension, hypertriglyceridemia, aspartate aminotransferase (AST), platelets, and the homeostasis model assessment of insulin resistance (HOMA-IR) were significantly associated with NASH. Age, gender, AST, alanine aminotransferase, alkaline phosphatase, platelets, total cholesterol, hypertension, and HOMA-IR, but not ethnicity, were significantly associated with advanced fibrosis. The effect of HOMA-IR on the risk of NASH was modified by ethnicity: HOMA-IR was not a significant risk factor for NASH among Latinos (odds ratio [OR] = 0.93; 95% confidence interval [CI]: 0.85-1.02), but was significant among non-Latino whites (OR, 1.06; 95% CI: 1.01-1.11).