Public Release Type:
Journal
Publication Year: 2012
Authors:
Kleiner DE,
Behling C,
Belt P,
Brunt EM,
Guy CD,
Neuschwander-Tetri BA,
Torbenson M,
Yeh MM
Studies:
Nonalcoholic Steatohepatitis Clinical Research Network
Hepatocyte glycogenosis is a change in which hepatocytes fi ll with glycogen and acquire a glassy, pale appearance on routine stains. Glycogenosis has been identifi ed as a dominant change in some type 1 diabetics biopsied for elevated aminotransferase levels. In this clinical situation, glycogenosis is thought to result from poor diabetic control. We have observed it in NAFLD, but its clinical and histologic associations are unknown. We sought to identify demographic, biochemical and histologic associations with glycogenosis in adults with NAFLD.