PubMed ID:
21779086
Public Release Type:
Journal
Publication Year: 2011
Affiliation: Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. Wadden@mail.med.upenn.edu
DOI:
https://doi.org/10.1038/oby.2011.230
Authors:
Bertoni AG,
Knowler WC,
Chen J,
Alexander T,
Allen L,
Allen M,
Anderson A,
Anderson E,
Arceci J,
Arceneaux J,
Armand B,
Azuero C,
Bach A,
Bachand A,
Bahnson JL,
Bain S,
Balasubramanyam A,
Bancroft B,
Bantle JP,
Barnes JM,
Barrett T,
Barr M,
Bartell J,
Bau S,
Beavers DP,
Beckner T,
Begay S,
Begnaud M,
Bell Y,
Bennett PH,
Berhard B,
Berkowitz RI,
Bertorelli A,
Bissett L,
Blackburn G,
Bloomquist P,
Blumenthal K,
Bolin P,
Bovaird E,
Bragg C,
Brancati FL,
Braunstein S,
Bray GA,
Brelje K,
Brewer A,
Brewer A,
Bright R,
Brock J,
Brozena S,
Burrington M,
Caballero AE,
Caderette E,
Cagliero E,
Campbell C,
Campbell C,
Carey R,
Carls J,
Carmean-Mihm T,
Carvajal R,
Cerniauskas B,
Charleston J,
Charron T,
Chen CH,
Chen H,
Chenot H,
Cheskin L,
Chmielewski J,
Chomentowski H,
Chong L,
Chula-Maguire K,
Clark D,
Clark JM,
Clark JM,
Coday M,
Coelho L,
Cohrs P,
Coleman CF,
Connelly S,
Cooper LS,
Costa T,
Coward P,
Craul K,
Craven BL,
Creel D,
Crerand C,
Crisler A,
Cronkite L,
Crow RS,
Crow S,
Currin J,
Curtis JM,
Cyr H,
Daly M,
Danchenko R,
Davenport R,
Davis C,
Delahanty L,
Delahanty LM,
Del Valle-Fagan T,
Devonish J,
Diamond A,
Diggins D,
DiLillo V,
Dobelstein A,
Dotson KM,
Duncan C,
Edmundowicz D,
Egan C,
Elnyczky B,
Espeland MA,
Evans M,
Ewing L,
Ewing S,
Fabricatore A,
Fallis B,
Fargnoli B,
Feeney PA,
Ferguson E,
Finch E,
Force D,
Foreyt JP,
Foss L,
Foster G,
Foushee R,
Fox A,
Friedman LM,
Gallagher K,
Garcia DO,
Gardner AC,
Gaur V,
Gaussoin SA,
Gauvin J,
Gee M,
Gilbert S,
Glasser S,
Glass J,
Glick H,
Gluck M,
Goebel-Fabbri A,
Goldberg L,
Goldman V,
Goode C,
Gorin A,
Granado D,
Greenberg D,
Green D,
Green S,
Greenway FL,
Gregg EW,
Gresham C,
Griffin J,
Griggs S,
Grove GA,
Guay H,
Haffner SM,
Hall NJ,
Hamdy O,
Hamilton A,
Hamilton J,
Hamilton M,
Hannum S,
Harlan V,
Harper PH,
Harrier S,
Harrison B,
Harvin L,
Hathaway K,
Hayashi C,
Hayward K,
Helbling NL,
Hensley S,
Hermes J,
Heshka S,
Hesson L,
Hill JO,
Hill JO,
Hillstrom KM,
Hirsch D,
Hodges A,
Hoelscher E,
Hogan P,
Holley V,
Hollowbreast DF,
Holowaty MA,
Horowitz M,
Horton ES,
Hubbard VS,
Hubbell A,
Hudak T,
Iqbal N,
Isaac JC,
Ives D,
Jackson SD,
Jakicic J,
Jakicic JM,
James LD,
Jeffery RW,
Johnson C,
Johnson KC,
Johnson M,
Johnson R,
Jones-Corneille L,
Jones J,
Jones L,
Jones L,
Jones P,
Joseph J,
Kahn S,
Kao A,
Kaufman P,
Keasler L,
Kelley DE,
Kieffer D,
Killean T,
King J,
King M,
Kitabchi AE,
Knopp R,
Konersman K,
Kora N,
Kores R,
Korytkowski M,
Krakoff J,
Krakoff J,
Kriska A,
Kuczmarski R,
Kuehnel R,
Kuller LH,
Kumanyika S,
LaFleur K,
Lambert J,
Lambert L,
Lambeth H,
Landry K,
Lane K,
Lang W,
Larkin M,
Lawlor MS,
Ledbury S,
Lee D,
Lefkowitz D,
Leshchinskiy E,
Lessard L,
Lewis CE,
Lichtermann L,
Lingle M,
Lipkin E,
Lipschutz P,
Li Y,
Look AHEAD Research Group,
Lorenzo C,
Luketic R,
Maddy VA,
Maeda J,
Maier D,
Malloy M,
Mancino J,
Mantzoros C,
Manus C,
Marcovina SM,
Maschak-Carey BJ,
Massaro JP,
Mathews A,
McNamara A,
Meacham M,
Michaels S,
Michalski K,
Michel T,
Miller GD,
Miller K,
Miller M,
Monk T,
Montez MG,
Montgomery B,
Moran R,
Morgan A,
Morgan T,
Mullen M,
Munkwitz L,
Murillo A,
Murray TY,
Nathan DM,
Neiberg RH,
Neiberg RH,
Nelson J,
Nevitt M,
Nicholson R,
Niggetts D,
Nyenwe E,
Ockenden T,
Oden L,
Otto A,
Otto AD,
Ovalle K,
Pal C,
Palencia J,
Palermo L,
Patricio J,
Patterson E,
Perault J,
Pera V,
Percy C,
Peters A,
Phelan S,
Pinto M,
Pi-Sunyer X,
Poorthunder P,
Pownall H,
Prineas RJ,
Puckett C,
Raatz SK,
Rahorst M,
Raines J,
Ramirez N,
Rau K,
Rau N,
Raynor D,
Raynor H,
Reboussin D,
Redmon JB,
Reeves RS,
Regensteiner J,
Rejeski WJ,
Reynolds PS,
Ribisl PM,
Rice BI,
Richmond BA,
Ritchea JR,
Robinson N,
Robles D,
Roche C,
Rome L,
Rubin R,
Ruelas V,
Ryan DH,
Ryan DH,
Saenz R,
Safford M,
Sangster S,
Sapun C,
Schmidt J,
Schwartz A,
Schwartz SS,
Scurlock N,
Sengardi SG,
Serafin-Dokhan S,
Shepherd J,
Shipp M,
Shovestull LA,
Skarphol T,
Smiley J,
Smith M,
Smith S,
Socha J,
Soliman EZ,
Spellman J,
Spellman K,
Steinberg DB,
Stevens C,
Stewart K,
Strate A,
Swartz L,
Tate D,
Tavares J,
Taylor JL,
Thomas A,
Thomas S,
Thorson C,
Toledo K,
Tomchee C,
Tonemah D,
Trence D,
Truman J,
Tsay R,
Tucker AD,
Tucker E,
Turgeon H,
Urda S,
Van Dorsten B,
Vitolins M,
Vitolins MZ,
Voeller MS,
Vosburg S,
Wadden TA,
Wadden TA,
Wagenknecht LE,
Walcheck C,
Walkup MP,
Wall K,
Webb N,
Wesche-Thobaben J,
Wesley A,
West DS,
White C,
Williams CC,
Williamson D,
Williamson DF,
Windham T,
Wing RR,
Wing RR,
Winning G,
Wolf DL,
Worley T,
Yamamoto ME,
Yanovski SZ,
Zhang P,
Zhang ZM
This report provides a further analysis of the year 4 weight losses in the Look AHEAD (Action for Health in Diabetes) study and identifies factors associated with long-term success. A total of 5,145 overweight/obese men and women with type 2 diabetes were randomly assigned to an intensive lifestyle intervention (ILI) or a usual care group, referred to as Diabetes Support and Education (DSE). ILI participants were provided approximately weekly group or individual treatment in year 1; continued but less frequent contact was provided in years 2-4. DSE participants received three group educational sessions in all years. As reported previously, at year 4, ILI participants lost an average of 4.7% of initial weight, compared with 1.1% for DSE (P < 0.0001). More ILI than DSE participants lost ≥ 5% (46% vs. 25%, P < 0.0001) and ≥ 10% (23% vs. 10%, P < 0.0001) of initial weight. Within the ILI, achievement of both the 5% and 10% categorical weight losses at year 4 was strongly related to meeting these goals at year 1. A total of 887 participants in ILI lost ≥ 10% at year 1, of whom 374 (42.2%) achieved this loss at year 4. Participants who maintained the loss, compared with those who did not, attended more treatment sessions and reported more favorable physical activity and food intake at year 4. These results provide critical evidence that a comprehensive lifestyle intervention can induce clinically significant weight loss (i.e., ≥ 5%) in overweight/obese participants with type 2 diabetes and maintain this loss in more than 45% of patients at 4 years.