PubMed ID:
21719096
Public Release Type:
Journal
Publication Year: 2011
Affiliation: Joslin Diabetes Center, Boston, MA, USA.
DOI:
https://doi.org/10.1016/S0140-6736(11)60886-6
Authors:
Gottlieb PA,
Liu S,
Abbondondolo M,
Abraham A,
Acosta B,
Adams T,
Adhikari S,
Adi S,
Ahenkorah B,
Albright-Fischer T,
Alford M,
Alies P,
Anderson M,
Anderson M,
Arazo L,
Arthur J,
Aye T,
Babu S,
Baden L,
Badias F,
Baker B,
Bassi M,
Batts E,
Beam C,
Becker D,
Becker D,
Becker DJ,
Benoist C,
Benoist C,
Berry B,
Bingley P,
Black M,
Blaschke C,
Bluestone J,
Blumberg E,
Blum J,
Bock M,
Boes MA,
Bollyky J,
Boonstra M,
Bosi E,
Boulware D,
Bourcier K,
Bourcier K,
Braun J,
Breen K,
Brendle F,
Brown A,
Brown D,
Buckingham BA,
Buckner J,
Bundy B,
Bundy B,
Chan M,
Chase HP,
Chase HP,
Christner L,
Cisneros M,
Clare-Salzler M,
Clare-Salzler M,
Cole G,
Colman P,
Conboy D,
Cook R,
Cordova E,
Cowie C,
Cowie C,
Cuthbertson D,
Davis R,
Delallo K,
Dickson B,
DiMeglio L,
DiMeglio L,
DiMeglio LA,
Dove A,
Eberhard C,
Eisel LA,
Eisenbarth GS,
Eisenbarth GS,
Esrey T,
Farkas K,
Fathman CG,
Fay S,
Fernandez S,
Finney L,
Fisher L,
Ford J,
Foulkes M,
Foulkes M,
Fradkin J,
Fradkin J,
Freeman D,
Gallagher MP,
Gibson C,
Ginem J,
Gitelman S,
Gitelman SE,
Gitelman SE,
Goland R,
Goland R,
Goland R,
Gottlieb P,
Gottlieb P,
Gottlieb P,
Granger M,
Grave G,
Greenbaum C,
Greenbaum C,
Greenbaum C,
Greenbaum CJ,
Greenbaum CJ,
Greenbaum CJ,
Greenberg E,
Green M,
Guillette H,
Gwynn D,
Haller M,
Halvorson M,
Hamilton C,
Hammond M,
Harden T,
Harding P,
Harrison L,
Hays B,
Hefty D,
Henry M,
Hering B,
Herold K,
Hess KO,
Hicks E,
Hilderman N,
Insel R,
Jalahej H,
Jeandron D,
Jordan S,
Kastelic W,
Kaufman FR,
Kaufman FR,
Kenyon NS,
Kieffer M,
Kis J,
Klein J,
Krause-Steinrauf H,
Krause-Steinrauf H,
Krause-Steinrauf H,
Krischer JP,
Krischer JP,
Krischer JP,
Krischer JP,
Kuhns K,
Lachin JM,
Lachin JM,
Lachin JM,
Lachin JM,
Laffel L,
Law P,
Lernmark A,
Leschek E,
Leschek E,
Leschek E,
Leschek E,
Libman I,
Linton C,
Lloyd J,
Lo B,
Loechelt B,
Loechelt B,
Mahon J,
Malozowski S,
Mancini D,
Marcovina S,
Marks J,
Marks JB,
Marks JB,
Matheson D,
McCulloch-Olson M,
McDonough S,
McGee PF,
Mendez M,
Michels A,
Mitchell H,
Monzavi R,
Monzavi R,
Moore DJ,
Moran A,
Moran A,
Moran A,
Muller S,
Naji A,
Nallamshetty L,
Nanto-Salonen K,
Nathan B,
Nepom G,
Nerup J,
Nicholson M,
O'Donnell R,
Orban T,
Orban T,
Orban T,
Orban T,
Orchard T,
Palmer JP,
Palmer JP,
Parkman R,
Parkman R,
Parrimon Y,
Paulus K,
Peakman M,
Perry J,
Pescovitz M,
Pescovitz M,
Peyman J,
Peyman J,
Phoebus D,
Pilger J,
Pittel E,
Pruneda L,
Pugliese A,
Pugliese A,
Quinlan S,
Rafkin L,
Rafkin L,
Rafkin L,
Raiden E,
Ramey M,
Ramiro J,
Raskin P,
Raskin P,
Raskin P,
Razack N,
Ricker A,
Ridge J,
Ridge J,
Rigby A,
Rigby A,
Riley K,
Ritzie AL,
Roberts A,
Rodriguez H,
Rodriguez H,
Rodriguez H,
Roncarolo MG,
Rosenthal SM,
Russell W,
Russell WE,
Russell WE,
Sadler K,
Sanda S,
Santiago I,
Savage P,
Savage P,
Savage P,
Schatz D,
Schatz D,
Schatz D,
Sherwin R,
Shor A,
Siegelman M,
Siegelman M,
Simell O,
Skyler JS,
Skyler JS,
Skyler JS,
Skyler JS,
Skyler JS,
Smith J,
Smith K,
Sosenko JM,
Soto A,
Spain L,
Spain L,
Spain L,
Spain L,
Sriskandarajah M,
Steffes M,
Terry A,
Thomas J,
Thomas JW,
Toledo F,
Torres N,
Trast J,
Tridgell D,
Trucco M,
Tsiatis A,
Type 1 Diabetes TrialNet Abatacept Study Group,
Veatch R,
Vendettuoli H,
Wagner J,
Wagner J,
Wagner J,
Wallace D,
Webber C,
Weinberg A,
Weinberg A,
Weiner L,
Wherrett D,
Wherrett D,
Wherrett D,
White P,
Wilson DM,
Wilson DM,
Wilson DM,
Winter W,
Winter W,
Wohlers G,
Wolfsdorf J,
Wood J,
Wootten M,
Xu P,
Young K,
Yu L,
Zafonte SJ,
Zhang H,
Ziegler A,
Zinman B
The immunopathogenesis of type 1 diabetes mellitus is associated with T-cell autoimmunity. To be fully active, immune T cells need a co-stimulatory signal in addition to the main antigen-driven signal. Abatacept modulates co-stimulation and prevents full T-cell activation. We evaluated the effect of abatacept in recent-onset type 1 diabetes.