PubMed ID:
21266329
Public Release Type:
Journal
Publication Year: 2011
Affiliation: Centre for Diabetes Research, Western Australian Institute for Medical Research, University of Western Australia, Crawley, Australia. gem@waimr.uwa.edu.au
DOI:
https://doi.org/10.2337/db10-1195
Authors:
Akolkar B,
Chen WM,
Erlich HA,
Hilner JE,
James I,
Julier C,
Mehta M,
Morahan G,
Nerup J,
Nierras C,
Pociot F,
Rich SS,
Todd JA,
Type 1 Diabetes Genetics Consortium
Studies:
Type 1 Diabetes Genetics Consortium
Interactions between genetic and environmental factors lead to immune dysregulation causing type 1 diabetes and other autoimmune disorders. Recently, many common genetic variants have been associated with type 1 diabetes risk, but each has modest individual effects. Familial clustering of type 1 diabetes has not been explained fully and could arise from many factors, including undetected genetic variation and gene interactions.