PubMed ID:
20980456
Public Release Type:
Journal
Publication Year: 2011
Affiliation: Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA. virellam@musc.edu
DOI:
https://doi.org/10.2337/db10-0915
Authors:
Baker NL,
Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group,
Hunt KJ,
Lachin J,
Lopes-Virella MF,
Nathan DM,
Virella G
Studies:
Diabetes Control and Complications Trial
High cholesterol levels in circulating immune complexes (IC), surrogate markers of modified LDL, are associated with increased carotid intima-media thickness (IMT) and cardiovascular events in type 1 diabetes. Different modifications of LDL are involved in IC formation, but which of these are predictive of vascular events is not known. Therefore, we measured oxidized LDL (oxLDL), advanced glycation end products-modified LDL (AGE-LDL), and malondialdehyde-modified LDL (MDA-LDL) in IC and determined their relationship with increased carotid IMT and compared the strength of the association with that observed with conventional risk factors.