Public Release Type:
Journal
Publication Year: 2010
Authors:
Schmidt S,
Abdelmalek MF,
Diehl AM,
Guy CD,
Hauser MA,
Johnson R,
Rimmler J,
Suzuki A,
Unalp A
Studies:
Nonalcoholic Steatohepatitis Clinical Research Network
In patients with nonalcoholic fatty liver disease (NAFLD), increased dietary fructose (FRU) intake has been associated with decreased hepatic ATP, increased uric acid (UA), hepatocellular injury and fibrosis. We hypothesized that FRU-related liver injury may be attributable to increased activity of fructokinase, or hexoketokinase (KHK), a key enzyme for fructose metabolism.