PubMed ID:
20648472
Public Release Type:
Journal
Publication Year: 2010
Affiliation: Department of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA. espeliotes@partners.org
DOI:
https://doi.org/10.1002/hep.23768
Authors:
Butler JL,
GIANT Consortium,
Hirschhorn JN,
MIGen Consortium,
NASH CRN,
Palmer CD,
Speliotes EK,
Voight BF
Studies:
Nonalcoholic Steatohepatitis Clinical Research Network
Single nucleotide polymorphisms (SNPs) near 7 loci have been associated with liver function tests or with liver steatosis by magnetic resonance spectroscopy. In this study we aim to test whether these SNPs influence the risk of histologically-confirmed nonalcoholic fatty liver disease (NAFLD). We tested the association of histologic NAFLD with SNPs at 7 loci in 592 cases of European ancestry from the Nonalcoholic Steatohepatitis Clinical Research Network and 1405 ancestry-matched controls. The G allele of rs738409 in PNPLA3 was associated with increased odds of histologic NAFLD (odds ratio [OR] = 3.26, 95% confidence intervals [CI] = 2.11-7.21; P = 3.6 x 10(-43)). In a case only analysis of G allele of rs738409 in PNPLA3 was associated with a decreased risk of zone 3 centered steatosis (OR = 0.46, 95% CI = 0.36-0.58; P = 5.15 x 10(-11)). We did not observe any association of this variant with body mass index, triglyceride levels, high- and low-density lipoprotein levels, or diabetes (P > 0.05). None of the variants at the other 6 loci were associated with NAFLD.