PubMed ID:
20682688
Public Release Type:
Journal
Publication Year: 2010
Affiliation: Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
DOI:
https://doi.org/10.2337/db10-0177
Authors:
Ackerman C,
Cox NJ,
Dunger DB,
Dyer AR,
Frayling TM,
Freathy RM,
HAPO Study Cooperative Research Group,
Hattersley AT,
Hayes MG,
Lee H,
Lowe LP,
Lowe WL Jr,
Metzger BE,
Urbanek M
Studies:
Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study
Common genetic variants in GCK and TCF7L2 are associated with higher fasting glucose and type 2 diabetes in nonpregnant populations. However, their associations with glucose levels from oral glucose tolerance tests (OGTTs) in pregnancy have not been assessed in a large sample. We hypothesized that these variants are associated with quantitative measures of glycemia in pregnancy.