Public Release Type:
Conference Presentation
Publication Year: 2022
Affiliation: 1Department of Pediatrics Division of Gastroenterology, Hepatology and Nutrition, Ann & Robert H. Lurie Children's Hospital of Chicago
2Department of Medicine, Northwestern University, Feinberg School of Medicine, Division of Gastroenterology and Hepatology
Authors:
LeCuyer B,
Hyon A,
Alyssa Kriegermeier A,
Green RM,
Liu X
Request IDs:
23474
Studies:
A Prospective Database of Infants With Cholestasis
Cholestatic liver diseases, including biliary atresia (BA), are the leading indication for pediatric liver transplant • The unfolded protein response (UPR) is an adaptive cellular response to endoplasmic reticulum (ER) stress which can be triggered by cholestasis • Hepatic IRE1a/XBP1 pathways of the UPR regulate response to ER stress, but their role in pediatric cholestatic liver injury remains unclear