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PubMed ID:
20121884
Public Release Type:
Journal
Publication Year: 2010
Affiliation: Joslin Diabetes Center/Harvard Medical School, Boston, MA, USA. amjacobson@winthrop.org
DOI:
https://doi.org/10.1111/j.1464-5491.2009.02885.x
Authors:
DCCT/EDIC Research Group,
Boright AP,
Harth J,
Silvers N,
Bayless M,
Weinger K,
Musen G,
Jacobson AM,
Paterson AD,
Ryan CM,
Cleary PA,
Waberski BH,
Dahms W
Studies:
Diabetes Control and Complications Trial
Specific polymorphisms of the apolipoprotein E (APOE) and angiotensin-converting enzyme (ACE) genes appear to increase risk for Alzheimer's disease and cognitive dysfunction in the general population, yet little research has examined whether genetic factors influence risk of cognitive dysfunction in patients with Type 1 diabetes. The long-term follow-up of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) population provides an opportunity to examine if specific genetic variations in APOE and ACE alter risk for cognitive decline.
