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Publication Information
Affiliation
Authors
Brunt E, Chalasani N, Cummings O, Tandra S, Unalp-Arida Aynur A, Vuppalanchi R, Wilson L, Yeh M
Studies
Citation
Tandra S, Vuppalanchi R, Cummings O, Brunt E, Yeh M, Wilson L, Unalp-Arida Aynur A, Chalasani N. Signifi cance of Microvesicular Steatosis in Nonalcoholic Fatty Liver Disease (NAFLD). AM J GASTROENTEROL 2009 Oct;104(S3):S157.Abstract
NAFLD is associated with accumulation of excess fat in hepatocytes
visualized as macrovesicular steatosis. Some patients with NAFLD also
have nonzonal aggregates of microvesicular steatosis but its significance is
unknown. Diffuse microvesicular steatosis is associated with mitochondrial
injury; a factor that plays an important role in the disease progression. We
evaluated the frequency of microvesicular steatosis and assessed its association
with histologic markers of severity in patients with NAFLD.