Public Release Type:
Journal
Publication Year: 2009
Authors:
Vuppalanchi R,
Chalasani N,
Brunt E,
Cummings O,
Tandra S,
Unalp-Arida Aynur A,
Wilson L,
Yeh M
Studies:
Nonalcoholic Steatohepatitis Clinical Research Network
NAFLD is associated with accumulation of excess fat in hepatocytes visualized as macrovesicular steatosis. Some patients with NAFLD also have nonzonal aggregates of microvesicular steatosis but its significance is unknown. Diffuse microvesicular steatosis is associated with mitochondrial injury; a factor that plays an important role in the disease progression. We evaluated the frequency of microvesicular steatosis and assessed its association with histologic markers of severity in patients with NAFLD.