Public Release Type:
Journal
Publication Year: 2009
Authors:
Aouizerat BE,
Bambha K,
Bass NM,
Ferrell L,
Unalp-Arida A
Studies:
Nonalcoholic Steatohepatitis Clinical Research Network
Nonalcoholic fatty liver disease (NAFLD) is intimately associated with insulin resistance and encompasses a spectrum of liver injury associated with hepatocyte lipid accumulation including, simple fatty liver (nonalcoholic steatosis, NAS), nonalcoholic steatohepatitis (NASH) and cirrhosis (NASH cirrhosis, NC). Adipokines (adiponectin [APN], leptin [LEP], resistin [RSTN]) and the adipocyte triglyceride regulating enzyme - hormone sensitive lipase [HSL], are important modulators of insulin sensitivity and thus, may play a role in NAFLD pathogenesis.