Public Release Type:
Journal
Publication Year: 2009
Authors:
Aouizerat BE,
Bambha K,
Bass NM,
Ferrell L,
Unalp-Arida A
Studies:
Nonalcoholic Steatohepatitis Clinical Research Network
Nonalcoholic fatty liver disease (NAFLD) is a prevalent liver disease, particularly in the Latino population, that is closely associated with insulin resistance and dyslipidemia and encompasses a spectrum of liver injury, ranging from simple fatty liver (nonalcoholic steatosis, NAS), to nonalcoholic steatohepatitis (NASH), to cirrhosis (NASH cirrhosis, NC). Adipokines (adiponectin [APN], leptin [LEP], resistin [RSTN]), along with adipogenic hormones (i.e. hormone sensitive lipase, [HSL]) influence sensitivity to insulin and metabolic processing of energy substrates and, as such, may play a role in NAFLD pathogenesis. Despite NAFLD being prevalent among Latinos, the mechanisms of NAFLD pathogenesis are relatively unexplored in this population.