PubMed ID:
19119263
Public Release Type:
Journal
Publication Year: 2009
Affiliation: Deparment of Family and Preventive Medicine, University of California San Diego, La Jolla, California, USA. vbhatnag@ucsd.edu
DOI:
https://doi.org/10.1038/ajh.2008.341
Authors:
Appel LJ,
AASK Study Investigators,
Bakris GL,
Bhatnagar V,
Brophy VH,
Contreras G,
Hiremath L,
Lipkowitz MS,
Middleton JP,
Nievergelt CM,
Norris KC,
O'Connor DT,
Richard E,
Salem RM,
Schork NJ,
Wright J
African Americans have a disproportionate burden of hypertension and comorbid disease. Pharmacogenetic markers of blood pressure response have yet to be defined clearly. This study explores the association between G-protein-coupled receptor kinase type 4 (GRK4) variants and blood pressure response to metoprolol among African Americans with early hypertensive nephrosclerosis.