PubMed ID:
15867184
Public Release Type:
Journal
Publication Year: 2005
Affiliation: Division of Preventive Medicine, Brigham and Womens Hospital, Boston, Mass, USA. dschaumberg@rics.bwh.harvard.edu
DOI:
https://doi.org/10.1161/01.CIR.0000165064.31505.3B
Authors:
Glynn RJ,
Jenkins AJ,
Lyons TJ,
Manson JE,
Nathan DM,
Ridker PM,
Rifai N,
Schaumberg DA
Studies:
Diabetes Control and Complications Trial
Type 1 diabetes mellitus is associated with an increased risk of cardiovascular disease (CVD) that is not fully explained by conventional risk factors. The Diabetes Control and Complications Trial (DCCT) showed that intensive diabetes therapy reduced levels of LDL cholesterol and triglycerides but increased the risk of major weight gain, which might adversely affect CVD risk. The present study examined the effect of intensive therapy on levels of several markers of inflammation that have been linked to risk of CVD.