PubMed ID:
12436340
Public Release Type:
Journal
Publication Year: 2002
Affiliation: Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
DOI:
https://doi.org/10.1007/s00125-002-0962-y
Authors:
Atchley DH,
Kenny D,
Lopes-Virella MF,
Virella G,
Zheng D
Studies:
Diabetes Control and Complications Trial
Oxidized LDL is immunogenic and immune complexes formed by oxidized LDL and corresponding antibodies are pro-atherogenic and pro-inflammatory. Considering that macroalbuminuria is a risk factor for coronary heart disease and that common pathogenic factors for atherosclerosis and glomerulosclerosis exist, our aim was to determine whether the amount and/or characteristics of oxidized LDL- anti-oxidized LDL complexes correlated with the degree of albuminuria in patients with Type I (insulin-dependent) diabetes mellitus.