PubMed ID:
12028466
Public Release Type:
Journal
Publication Year: 2002
Affiliation: Division of Nephrology Department of Medicine, University of California Davis, 95616, USA. gakaysen@ucdavis.edu
DOI:
https://doi.org/10.1046/j.1523-1755.2002.00076.x
Authors:
Dubin JA,
Kaysen GA,
Levin NW,
Mitch WE,
Müller HG,
Rosales LM
Studies:
Hemodialysis Study
Serum albumin concentration is a balance among its synthesis rate, fractional catabolic rate (FCR), distribution, dilution in the plasma pool and external loss. The physiologic bases for establishing the level of serum albumin in hemodialysis patients have not been defined despite the association of hypoalbuminemia with excess mortality. Albumin concentration is associated with the levels of several acute phase proteins (APPs), C-reactive protein (CRP), alpha1 acid glycoprotein (alpha1 AG), or ceruloplasmin, and with nutritional markers, such as normalized protein catabolic rate (nPCR).