PubMed ID:
10571804
Public Release Type:
Journal
Publication Year: 1999
Affiliation: NIDDK, National Institutes of Health, Bethesda, MD, USA. jtdaugir@uic.edu
DOI:
https://doi.org/10.1046/j.1523-1755.1999.00726.x
Authors:
Greene T,
Daugirdas JT,
Depner TA,
Gotch FA,
Star RA
Studies:
Hemodialysis Study
The volume of urea distribution (V) is usually derived from single-pool variable volume urea kinetics. A theoretical analysis has shown that modeled single-pool V (Vsp) is overestimated when the urea reduction ratio (URR) is greater than 65 to 70% and is underestimated when the URR is less than 65%. The "true" volume derived from double-pool kinetics (Vdp) does not exhibit this effect. An equation has been derived to adjust Vsp to the expected Vdp.