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PubMed ID:
7894522
Public Release Type:
Journal
Publication Year: 1994
Affiliation: Department of Medicine, University of Toronto, St Michael's Hospital, Ontario, Canada.
Authors:
Ferguson RS,
Cleary PA,
MacLean S,
Simkins S,
Zinman B,
Leiter LA,
Lukaski HC,
Kenny DJ,
Barnie A,
Camelon K
Studies:
Diabetes Control and Complications Trial
Although weight gain often accompanies intensive treatment regimens designed to achieve near-normal glycemia in insulin-dependent diabetes mellitus (IDDM), body composition (BC) has not been well studied. Bioelectrical impedance analysis (BIA) is a safe, rapid, and non-invasive method of assessing BC but has not been utilized widely in IDDM. Data from 46 adults with IDDM were used to develop a regression model estimating fat-free body mass (FFM) from bioimpedance measurements obtained using a proximal electrode placement. Reference values of FFM were determined by dual x-ray absorptiometry (DXA). A model using the ratio of height squared to the minimum resistance of 4 limb-lead combinations (H2/R), total body weight, and a weight-gender interaction achieved a high level of accuracy (R2 = 0.982, residual standard deviation = 1.43 kg), while studies of 10 subjects before and after a light meal found no short-term effect of glycemia on measured BIA variables. BIA will therefore be used in combination with waist-to-hip ratios to study the composition and distribution of the increased weight associated with intensive therapy in the DCCT.
