The National Institutes of Health (NIH) has announced a new critical research priority: Leveraging Research Resources to Accelerate Innovation and Improve Rigor for Chronic and Comorbid Disease Research and Discovery (https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/120). This highlighted topic encourages investigators to make strategic use of existing repositories, datasets, and specimens to generate fresh insights into disease mechanisms, prevention strategies, diagnostic approaches, and treatment development. The NIDDK Central Repository provides access to a wide array of high-quality, multimodal data and specimens from clinical trials and research consortia. These ready-to-use resources rapidly strengthen your study design, enhance rigor, and accelerate innovation. Fast‑track and elevate your next research breakthrough!