PubMed ID:
30211831
Public Release Type:
Journal
Publication Year: 2019
Affiliation: Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.
DOI:
https://doi.org/10.1097/TP.0000000000002425
Authors:
Bayman L,
Berne C,
Bridges N,
Eggerman T,
Foss A,
Goldstein J,
Jenssen T,
Jorns C,
Korsgren O,
Lundgren T,
Morrison Y,
Nilsson B,
Rydén M,
Schwieger T,
Tufveson G,
von Zur-Mühlen B
Studies:
Safety and Effectiveness of Low Molecular Weight Sulfated Dextran in Islet Transplantation
When transplanted human pancreatic islets are exposed to blood during intraportal infusion, an innate immune response is triggered. This instant blood-mediated inflammatory reaction (IBMIR) activates the coagulation and complement cascades and leads to the destruction of 25% of all transplanted islets within minutes, contributing to the need, in most patients, for islets from more than 1 donor. Low molecular dextran sulfate (LMW-DS) has been shown in experimental settings to inhibit IBMIR.