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Publication Information
Affiliation
Barbara Davis Center for Childhood Diabetes, School of Medicine, University of Colorado, Aurora, Colorado.
Authors
Frohnert BI, Krumsiek J, Laimighofer M, Norris JM, Rewers MJ, Steck AK, Theis FJ, Winkler C, Ziegler AG
Studies
Citation
Frohnert BI, Laimighofer M, Krumsiek J, Theis FJ, Winkler C, Norris JM, Ziegler AG, Rewers MJ, Steck AK. Prediction of type 1 diabetes using a genetic risk model in the Diabetes Autoimmunity Study in the Young. Pediatr Diabetes 2018 Mar;19(2):277-283. Epub 2017 Jul 11.Abstract
Genetic predisposition for type 1 diabetes (T1D) is largely determined by human leukocyte antigen (HLA) genes; however, over 50 other genetic regions confer susceptibility. We evaluated a previously reported 10-factor weighted model derived from the Type 1 Diabetes Genetics Consortium to predict the development of diabetes in the Diabetes Autoimmunity Study in the Young (DAISY) prospective cohort. Performance of the model, derived from individuals with first-degree relatives (FDR) with T1D, was evaluated in DAISY general population (GP) participants as well as FDR subjects.