PubMed ID:
28695611
Public Release Type:
Journal
Publication Year: 2018
Affiliation: Barbara Davis Center for Childhood Diabetes, School of Medicine, University of Colorado, Aurora, Colorado.
DOI:
https://doi.org/10.1111/pedi.12543
Authors:
Frohnert BI,
Krumsiek J,
Laimighofer M,
Norris JM,
Rewers MJ,
Steck AK,
Theis FJ,
Winkler C,
Ziegler AG
Request IDs:
21213
Studies:
Type 1 Diabetes Genetics Consortium
Genetic predisposition for type 1 diabetes (T1D) is largely determined by human leukocyte antigen (HLA) genes; however, over 50 other genetic regions confer susceptibility. We evaluated a previously reported 10-factor weighted model derived from the Type 1 Diabetes Genetics Consortium to predict the development of diabetes in the Diabetes Autoimmunity Study in the Young (DAISY) prospective cohort. Performance of the model, derived from individuals with first-degree relatives (FDR) with T1D, was evaluated in DAISY general population (GP) participants as well as FDR subjects.