NIDDK Central Repository - APOL1-associated glomerular disease among African-American children: a collaboration of the Chronic Kidney Disease in Children (CKiD) and Nephrotic Syndrome Study Network (NEPTUNE) cohorts.

An official website of the United States government

NIDDK Central Repository

Publication Information

DOI

10.1093/ndt/gfw061

PubMed ID

27190333

Public Release Type

Journal

Publication Year

2017

Affiliation

Division of Pediatric Nephrology, University of Michigan School of Medicine, Ann Arbor, MI, USA.

Authors

Furth SL, Gibson KL, Gillies CE, Hingorani S, Hjorten R, Kaskel FJ, Kopp JB, Kretzler M, Limou S, Moxey-Mims M, Ng DK, Reidy KJ, Robertson CC, Sampson MG, Sedor JR, Sethna CB, Warady BA, Winkler CA, Woroniecki RP

Studies

CKiD

Citation

Ng DK, Robertson CC, Woroniecki RP, Limou S, Gillies CE, Reidy KJ, Winkler CA, Hingorani S, Gibson KL, Hjorten R, Sethna CB, Kopp JB, Moxey-Mims M, Furth SL, Warady BA, Kretzler M, Sedor JR, Kaskel FJ, Sampson MG. APOL1-associated glomerular disease among African-American children: a collaboration of the Chronic Kidney Disease in Children (CKiD) and Nephrotic Syndrome Study Network (NEPTUNE) cohorts. Nephrol Dial Transplant 2017 Jun 1;32(6):983-990.

Abstract

Individuals of African ancestry harboring two variant alleles within apolipoprotein L1 ( APOL1 ) are classified with a high-risk (HR) genotype. Adults with an HR genotype have increased risk of focal segmental glomerulosclerosis and chronic kidney disease compared with those with a low-risk (LR) genotype (0 or 1 variants). The role of APOL1 risk genotypes in children with glomerular disease is less well known.