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PubMed ID:
27190333
Public Release Type:
Journal
Publication Year: 2017
Affiliation: Division of Pediatric Nephrology, University of Michigan School of Medicine, Ann Arbor, MI, USA.
DOI:
https://doi.org/10.1093/ndt/gfw061
Authors:
Hingorani S,
Ng DK,
Robertson CC,
Woroniecki RP,
Limou S,
Gillies CE,
Reidy KJ,
Winkler CA,
Gibson KL,
Hjorten R,
Sethna CB,
Kopp JB,
Moxey-Mims M,
Furth SL,
Warady BA,
Kretzler M,
Sedor JR,
Kaskel FJ,
Sampson MG
Studies:
The Chronic Kidney Disease in Children Cohort Study
Individuals of African ancestry harboring two variant alleles within apolipoprotein L1 ( APOL1 ) are classified with a high-risk (HR) genotype. Adults with an HR genotype have increased risk of focal segmental glomerulosclerosis and chronic kidney disease compared with those with a low-risk (LR) genotype (0 or 1 variants). The role of APOL1 risk genotypes in children with glomerular disease is less well known.
