PubMed ID:
26344576
Public Release Type:
Journal
Publication Year: 2016
Affiliation: Janssen Research and Development, Beerse, Belgium.
DOI:
https://doi.org/10.1111/liv.12932
Authors:
Aerssens J,
Darling J,
Fanning G,
Fried MW,
Johansson S,
Talloen W,
Tuefferd M
Request IDs:
10433
Studies:
Viral Resistance to Antiviral Therapy of Chronic Hepatitis C
Sustained virological response (SVR) following peginterferon (pegIFN) and ribavirin (RBV) treatment in hepatitis C virus (HCV)-infected patients has been linked with the IL28B genotype and lower peripheral levels of the CXCR3-binding chemokine IP-10 (CXCL10). To further improve the understanding of these biomarkers we investigated plasma levels of the other CXCR3-binding chemokines and activity of the dipeptidyl peptidase IV (DPP4, CD26) protease, which cleaves IP-10, in relation to treatment response.