PubMed ID:
26186989
Public Release Type:
Journal
Publication Year: 2015
Affiliation: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
DOI:
https://doi.org/10.1016/j.jhep.2015.06.035
Authors:
Bonkovsky HL,
Chen S,
Edlin BR,
Howell CD,
Kirk GD,
Kuniholm MH,
Lang Kuhs KA,
Morgan TR,
O'Brien TR,
Paquin A,
Pfeiffer RM,
Prokunina-Olsson L,
Strickler HD,
Thomas DL
Request IDs:
10835
Studies:
The Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis Trial
,
Viral Resistance to Antiviral Therapy of Chronic Hepatitis C
Genetic polymorphisms within the interferon lambda (IFN-λ) region are strongly associated with hepatitis C virus (HCV) clearance; the IFNL4-ΔG/TT (rs368234815) polymorphism, which controls the generation of IFN-λ4 protein, is more strongly associated with HCV clearance than rs12979860 (the 'IL28B variant'). An IFNL3 3' untranslated region polymorphism (rs4803217) has been proposed as a causal variant that may affect HCV clearance by altering IFNL3 mRNA stability.