NIDDK Central Repository - Comparison of functional variants in IFNL4 and IFNL3 for association with HCV clearance.

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NIDDK Central Repository

Publication Information

DOI

10.1016/j.jhep.2015.06.035

PubMed ID

26186989

Public Release Type

Journal

Publication Year

2015

Affiliation

Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

Authors

Bonkovsky HL, Chen S, Edlin BR, Howell CD, Kirk GD, Kuniholm MH, Lang Kuhs KA, Morgan TR, O'Brien TR, Paquin A, Pfeiffer RM, Prokunina-Olsson L, Strickler HD, Thomas DL

Studies

Virahep-C, HALT-C

Citation

O'Brien TR, Pfeiffer RM, Paquin A, Lang Kuhs KA, Chen S, Bonkovsky HL, Edlin BR, Howell CD, Kirk GD, Kuniholm MH, Morgan TR, Strickler HD, Thomas DL, Prokunina-Olsson L. Comparison of functional variants in IFNL4 and IFNL3 for association with HCV clearance. J Hepatol 2015 Nov;63(5):1103-10. Epub 2015 Jul 15.

Abstract

Genetic polymorphisms within the interferon lambda (IFN-λ) region are strongly associated with hepatitis C virus (HCV) clearance; the IFNL4-ΔG/TT (rs368234815) polymorphism, which controls the generation of IFN-λ4 protein, is more strongly associated with HCV clearance than rs12979860 (the 'IL28B variant'). An IFNL3 3' untranslated region polymorphism (rs4803217) has been proposed as a causal variant that may affect HCV clearance by altering IFNL3 mRNA stability.