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Publication Information

PubMed ID
Public Release Type
Journal
Publication Year
2015
Affiliation
Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Authors
Bonkovsky HL, Chen S, Edlin BR, Howell CD, Kirk GD, Kuniholm MH, Lang Kuhs KA, Morgan TR, O'Brien TR, Paquin A, Pfeiffer RM, Prokunina-Olsson L, Strickler HD, Thomas DL
Citation
O'Brien TR, Pfeiffer RM, Paquin A, Lang Kuhs KA, Chen S, Bonkovsky HL, Edlin BR, Howell CD, Kirk GD, Kuniholm MH, Morgan TR, Strickler HD, Thomas DL, Prokunina-Olsson L. Comparison of functional variants in IFNL4 and IFNL3 for association with HCV clearance. J Hepatol 2015 Nov;63(5):1103-10. Epub 2015 Jul 15.

Abstract

Genetic polymorphisms within the interferon lambda (IFN-λ) region are strongly associated with hepatitis C virus (HCV) clearance; the IFNL4-ΔG/TT (rs368234815) polymorphism, which controls the generation of IFN-λ4 protein, is more strongly associated with HCV clearance than rs12979860 (the 'IL28B variant'). An IFNL3 3' untranslated region polymorphism (rs4803217) has been proposed as a causal variant that may affect HCV clearance by altering IFNL3 mRNA stability.