PubMed ID:
25921377
Public Release Type:
Journal
Publication Year: 2015
Affiliation: Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota.
DOI:
https://doi.org/10.1053/j.gastro.2015.04.020
Authors:
Talley NJ,
Abraham BP,
Almazar AE,
Bouras EP,
Camilleri M,
DiBaise JK,
El-Serag HB,
Hamilton FA,
Herrick LM,
Howden CW,
Lacy BE,
Locke GR,
Moayyedi P,
Prather CM,
Saito YA,
Schleck CD,
Szarka LA,
Tilkes KE,
Zinsmeister AR
Studies:
Functional Dyspepsia Treatment Trial
Antidepressants are frequently prescribed to treat functional dyspepsia (FD), a common disorder characterized by upper abdominal symptoms, including discomfort or postprandial fullness. However, there is little evidence of the efficacy of these drugs in patients with FD. We performed a randomized, double-blind, placebo-controlled trial to evaluate the effects of antidepressant therapy on symptoms, gastric emptying (GE), and meal-induced satiety in patients with FD.