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Publication Information
Affiliation
Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota.
Authors
Abraham BP, Almazar AE, Bouras EP, Camilleri M, DiBaise JK, El-Serag HB, Hamilton FA, Herrick LM, Howden CW, Lacy BE, Locke GR, Moayyedi P, Prather CM, Saito YA, Schleck CD, Szarka LA, Talley NJ, Tilkes KE, Zinsmeister AR
Studies
Citation
Talley NJ, Locke GR, Saito YA, Almazar AE, Bouras EP, Howden CW, Lacy BE, DiBaise JK, Prather CM, Abraham BP, El-Serag HB, Moayyedi P, Herrick LM, Szarka LA, Camilleri M, Hamilton FA, Schleck CD, Tilkes KE, Zinsmeister AR. Effect of Amitriptyline and Escitalopram on Functional Dyspepsia: A Multicenter, Randomized Controlled Study. Gastroenterology 2015 Aug;149(2):340-9.e2. Epub 2015 Apr 25.Abstract
Antidepressants are frequently prescribed to treat functional dyspepsia (FD), a common disorder characterized by upper abdominal symptoms, including discomfort or postprandial fullness. However, there is little evidence of the efficacy of these drugs in patients with FD. We performed a randomized, double-blind, placebo-controlled trial to evaluate the effects of antidepressant therapy on symptoms, gastric emptying (GE), and meal-induced satiety in patients with FD.