PubMed ID:
25906075
Public Release Type:
Journal
Publication Year: 2015
Affiliation: Department of Internal Medicine, Division of Nephrology, University of New Mexico, Albuquerque, New Mexico, United States of America.
DOI:
https://doi.org/10.1371/journal.pone.0123784
Authors:
Argyropoulos C,
Unruh ML
Request IDs:
348
Studies:
Hemodialysis Study
Randomized Controlled Trials almost invariably utilize the hazard ratio calculated with a Cox proportional hazard model as a treatment efficacy measure. Despite the widespread adoption of HRs, these provide a limited understanding of the treatment effect and may even provide a biased estimate when the assumption of proportional hazards in the Cox model is not verified by the trial data. Additional treatment effect measures on the survival probability or the time scale may be used to supplement HRs but a framework for the simultaneous generation of these measures is lacking.