An official website of the United States government

Publication Information

PubMed ID
Public Release Type
Journal
Publication Year
2014
Affiliation
Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA; Salt Lake City VA Health Care System, Salt Lake City, UT, USA.
Authors
Greene T, Raphael KL, Ying J, Zhang Y
Studies
Citation
Raphael KL, Zhang Y, Ying J, Greene T. Prevalence of and risk factors for reduced serum bicarbonate in chronic kidney disease. Nephrology (Carlton) 2014 Oct;19(10):648-54.

Abstract

The prevalence of metabolic acidosis increases as glomerular filtration rate falls. However, most patients with stage 4 chronic kidney disease have normal serum bicarbonate concentration while some with stage 3 chronic kidney disease have low serum bicarbonate, suggesting that other factors contribute to generation of acidosis. The purpose of this study is to identify risk factors, other than reduced glomerular filtration rate, for reduced serum bicarbonate in chronic kidney disease.