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Publication Information
Affiliation
Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
Authors
Avant L, Barakat F, Bernard T, Blei AT, Brown R Jr, Campbell M, Casson D, Chung R, Coultrup S, Crippin JS, Davern TJ, Emre S, Fontana RJ, Gerstle L, Gottstein J, Groettum C, Grønbaek H, Han S, Harrison M, Hassenein T, Hay J, Huntley N, Hynan LS, Ingram K, Lalani E, Larson AM, Laursen TL, Lee WM, McCashland TM, McGuire B, Misra C, Morton D, Munoz S, Murray N, Partovi K, Peacock V, Pezzia C, Polson J, Prosser C, Reddy R, Reisch JS, Reuben A, Rossaro L, Rush R, Salvatori J, Sandahl TD, Satyanarayana R, Schilsky M, Schiødt FV, Schwartz J, Senkbeil L, Shakil A, Smith A, Støy S, Stravitz T, Taylor W, Thiel S, US Acute Liver Failure Study Group, Vilstrup H, Welch S, Zaman A
Studies
Citation
Laursen TL, Sandahl TD, Støy S, Schiødt FV, Lee WM, Vilstrup H, Thiel S, Grønbaek H, US Acute Liver Failure Study Group. Circulating mannan-binding lectin, M-, L-, H-ficolin and collectin-liver-1 levels in patients with acute liver failure. Liver Int 2015 Mar;35(3):756-63. Epub 2014 Sep 30.Abstract
The complement system is activated in liver diseases including acute liver failure (ALF); however, the role of the lectin pathway of complement has scarcely been investigated in ALF. The pathway is initiated by soluble pattern recognition molecules: mannan-binding lectin (MBL), M-, L-, and H-ficolin and collectin-liver-1 (CL-L1), which are predominantly synthesized in the liver. We aimed to study lectin levels in ALF patients and associations with clinical outcome.