NIDDK Central Repository - Association of low numbers of CD206-positive cells with loss of ICC in the gastric body of patients with diabetic gastroparesis.

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NIDDK Central Repository

Publication Information

DOI

10.1111/nmo.12389

PubMed ID

25041465

Public Release Type

Journal

Publication Year

2014

Affiliation

Enteric NeuroScience Program, Mayo Clinic, Rochester, MN, USA.

Authors

Abell TL, Bernard CE, Farrugia G, Froschauer L, Gibbons SJ, Hamilton FA, Harbison S, Hasler WL, Kendrick ML, Koch KL, Mann IS, McCallum RW, Nguyen LA, NIDDK Gastroparesis Clinical Research Consortium (GpCRC), Parkman HP, Pasricha PJ, Sarosiek I, Shen KR, Snape WJ, Tonascia J

Studies

NORIG

Citation

Bernard CE, Gibbons SJ, Mann IS, Froschauer L, Parkman HP, Harbison S, Abell TL, Snape WJ, Hasler WL, McCallum RW, Sarosiek I, Nguyen LA, Koch KL, Tonascia J, Hamilton FA, Kendrick ML, Shen KR, Pasricha PJ, Farrugia G, NIDDK Gastroparesis Clinical Research Consortium (GpCRC). Association of low numbers of CD206-positive cells with loss of ICC in the gastric body of patients with diabetic gastroparesis. Neurogastroenterol Motil 2014 Sep;26(9):1275-84. Epub 2014 Jul 13.

Abstract

There is increasing evidence for specific cellular changes in the stomach of patients with diabetic (DG) and idiopathic (IG) gastroparesis. The most significant findings are loss of interstitial cells of Cajal (ICC), neuronal abnormalities, and an immune cellular infiltrate. Studies done in diabetic mice have shown a cytoprotective effect of CD206+ M2 macrophages. To quantify overall immune cellular infiltrate, identify macrophage populations, and quantify CD206+ and iNOS+ cells. To investigate associations between cellular phenotypes and ICC.