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PubMed ID:
25041465
Public Release Type:
Journal
Publication Year: 2014
Affiliation: Enteric NeuroScience Program, Mayo Clinic, Rochester, MN, USA.
DOI:
https://doi.org/10.1111/nmo.12389
Authors:
NIDDK Gastroparesis Clinical Research Consortium (GpCRC),
Pasricha PJ,
Abell TL,
Snape WJ,
Hasler WL,
McCallum RW,
Sarosiek I,
Nguyen LA,
Koch KL,
Tonascia J,
Hamilton FA,
Kendrick ML,
Shen KR,
Harbison S,
Farrugia G,
Bernard CE,
Gibbons SJ,
Mann IS,
Froschauer L,
Parkman HP
Studies:
Gastroparesis Clinical Research Consortium
,
Nortriptyline for Idiopathic Gastroparesis
There is increasing evidence for specific cellular changes in the stomach of patients with diabetic (DG) and idiopathic (IG) gastroparesis. The most significant findings are loss of interstitial cells of Cajal (ICC), neuronal abnormalities, and an immune cellular infiltrate. Studies done in diabetic mice have shown a cytoprotective effect of CD206+ M2 macrophages. To quantify overall immune cellular infiltrate, identify macrophage populations, and quantify CD206+ and iNOS+ cells. To investigate associations between cellular phenotypes and ICC.
