Introduction: Biomarker risk prediction of contrast-associated acute kidney injury (CA-AKI) and major adverse kidney events (MAKE) may inform primary and secondary prevention strategies. We assessed the predictive accuracy of kidney stress and cardiac biomarkers to predict the risk of CA-AKI and MAKE at day 90 among patients with chronic kidney disease undergoing angiography. Methods: We analyzed a subset of participants from the Prevention of Serious Adverse Events following Angiography (PRESERVE) trial and measured urinary tissue inhibitor of matrix metalloproteinase [TIMP]-2 and insulin growth factor binding protein [IGFBP]-7 in 742 subjects and plasma beta natriuretic peptide [BNP] and high sensitivity C-reactive protein [hs-CRP], and serum troponin [Tn]) in 854 subjects using samples obtained 1-2 hours before and 2-4 hours after angiography. Results: Of 922 participants, 73 (7.9%) and 60 (6.5%) participants experienced CA-AKI and MAKE, respectively. None of the post-angiography biomarkers were associated with CA-AKI. Pre- and post-angiography median plasma BNP (pre: 200.0 vs. 71.5, pg/mL, P=0.049; post: 173 vs. 81 pg/mL, P=0.02), serum Tn (pre: 0.03 vs. 0.01, ng/mL, P<0.001; post, 0.04 vs. 0.02, ng/mL, P=0.01) and hs-CRP (pre: 9.3 vs. 3.4 mg/L, P=0.01; post: 9.9 vs. 3.2 mg/L, P=0.002) concentrations were higher among those who experienced MAKE, though their discriminatory capacity was only modest (AUROC <0.7). Conclusions: The lack of significant differences in biomarkers suggests that most mild CA-AKI cases may be mediated by hemodynamic changes rather than intrinsic kidney injury. Pre- and post-angiography plasma BNP, hs-CRP, and serum Tn modestly predict MAKE and might serve to augment risk prediction.