PubMed ID:
24389650
Public Release Type:
Journal
Publication Year: 2014
Affiliation: Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, MLC: 7022, 3333 Burnet Avenue, Cincinnati, OH, 45229-3039, USA, mark.mitsnefes@cchmc.org.
DOI:
https://doi.org/10.1007/s00467-013-2642-1
Authors:
CKiD study group,
Friedman LA,
Furth S,
Gordillo R,
Mitsnefes M,
Scherer PE,
Warady BA
Studies:
The Chronic Kidney Disease in Children Cohort Study
Chronic kidney disease (CKD) is associated with increased incidence of cardiac dysfunction. Recent animal studies have demonstrated that elevated levels of ceramides cause dilated lipotoxic cardiomyopathy. We hypothesized ceramides are increased in children with CKD and associated with abnormal cardiac structure and function.