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Publication Information
Affiliation
The Johns Hopkins Hospital, Baltimore, Maryland.
Authors
Abell TL, Farrugia G, Hamilton F, Hasler WL, Koch KL, Lee L, McCallum RW, Nguyen L, Parkman HP, Pasricha PJ, Sarosiek I, Snape WJ, Tonascia J, Unalp-Arida A, Van Natta ML
Studies
Citation
Parkman HP, Van Natta ML, Abell TL, McCallum RW, Sarosiek I, Nguyen L, Snape WJ, Koch KL, Hasler WL, Farrugia G, Lee L, Unalp-Arida A, Tonascia J, Hamilton F, Pasricha PJ. Effect of nortriptyline on symptoms of idiopathic gastroparesis: the NORIG randomized clinical trial. JAMA 2013 Dec 25;310(24):2640-9.Abstract
Gastroparesis remains a challenging syndrome to manage, with few effective treatments and a lack of rigorously controlled trials. Tricyclic antidepressants are often used to treat refractory symptoms of nausea, vomiting, and abdominal pain. Evidence from well-designed studies for this use is lacking.