PubMed ID:
23609896
Public Release Type:
Journal
Publication Year: 2013
Affiliation: Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
DOI:
https://doi.org/10.1097/MPG.0b013e318296e525
Authors:
Friedman JR,
Hand NJ,
Karjoo S,
Loarca L,
Russo PA,
Wells RG
Studies:
A Prospective Database of Infants With Cholestasis
Biliary atresia (BA) is a rapidly progressive form of biliary fibrosis affecting neonates. We previously reported that primary cilia on the intrahepatic cholangiocytes of patients with both syndromic and nonsyndromic BA were structurally abnormal. Our objective was to determine whether extrahepatic cholangiocytes in human biliary atresia, intrahepatic and extrahepatic cholangiocytes of rhesus rotavirus (RRV)-infected neonatal mice, and RRV-infected primary neonatal extrahepatic cholangiocytes also demonstrate ciliary abnormalities.