PubMed ID:
23882708
Public Release Type:
Journal
Publication Year: 2013
Affiliation: George Washington University, Rockville, Maryland 20852, USA. cleary@bsc.gwu.edu
DOI:
https://doi.org/10.1089/dia.2012.0316
Authors:
Anderson K,
Barnie A,
Braffett BH,
Cleary PA,
Cowie C,
DCCT/EDIC Research Group,
Gubitosi-Klug RA,
Lyons TJ,
Maynard J,
Orchard T,
Villavicencio S,
Way J
Studies:
Diabetes Control and Complications Trial
The Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications(EDIC) studies have established multiyear mean hemoglobin A1c (HbA1c) as predictive of microvascular complications in persons with type 1 diabetes. However, multiyear mean HbA1c is not always available in the clinical setting. Skin advanced glycation end products (AGEs) are thought to partially reflect effects of hyperglycemia over time, and measurement of skin AGEs might be a surrogate for multiyear mean HbA1c. As certain AGEs fluoresce and skin fluorescence has been demonstrated to correlate with the concentration of skin AGEs, noninvasive measurement by skin intrinsic fluorescence(SIF) facilitates the exploration of the association of mean HbA1c and other clinical/technical factors with SIF using the detailed phenotypic database available in DCCT/EDIC.