Public Release Type:
Journal
Publication Year: 2013
Authors:
Cheng J,
Joyce A,
Sanyal AJ,
Yates KP
Studies:
Nonalcoholic Steatohepatitis Clinical Research Network
,
Pioglitazone vs Vitamin E vs Placebo for Treatment of Non-Diabetic Patients With Nonalcoholic Steatohepatitis
The PIVENS (Pioglitazone versus Vitamin E versus Placebo for the Treatment of Nondiabetic Patients with Nonalcoholic Steatohepatitis (NASH)) trial demonstrated that Vitamin E improved NASH in 43% of the treated subjects. The mechanisms for the histological improvement are unknown. Elucidation of this mechanism will aid in understanding why only some subjects respond to vitamin E.