NIDDK Central Repository - Response to Vitamin E for Non-Alcoholic Steatohepatitis (NASH): What Is the Mechanism?

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NIDDK Central Repository

Publication Information

Public Release Type

Journal

Publication Year

2013

Authors

Cheng J, Joyce A, Sanyal AJ, Yates KP

Studies

PIVENS

Citation

Cheng J, Joyce A, Yates KP, Sanyal AJ. Response to Vitamin E for Non-Alcoholic Steatohepatitis (NASH): What Is the Mechanism? Gastroenterology 2013 May;144(Issue 5, Supplement 1):S-1012.

Abstract

The PIVENS (Pioglitazone versus Vitamin E versus Placebo for the Treatment of Nondiabetic Patients with Nonalcoholic Steatohepatitis (NASH)) trial demonstrated that Vitamin E improved NASH in 43% of the treated subjects. The mechanisms for the histological improvement are unknown. Elucidation of this mechanism will aid in understanding why only some subjects respond to vitamin E.