Vuppalanchi R, Deppe RB, Yates KP, Comerford M, Masuoka HC, Tetri BA, Loomba R, Brunt E, Kleiner DE, Tonascia J, Chalasani NP. Changes in Serum Cytokeratin 18 Levels Significantly Predict Changes in Liver Histology in Adults With Nonalcoholic Steatohepatitis: Results From the Pivens Trial. Gastroenterology 2013 May;144(Issue 5, Supplement 1):S-951.
Abstract
Previous cross-sectional studies have shown that serum levels of cytokeratin
fragments (CK18) are associated with the presence of steatohepatitis in individuals with
nonalcoholic fatty liver disease (NAFLD). However, it is unknown if serial serum CK18
levels can predict longitudinal changes in liver histology in NAFLD.