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Publication Information

Public Release Type
Journal
Publication Year
2013
Authors
Brunt E, Chalasani NP, Comerford M, Deppe RB, Kleiner DE, Loomba R, Masuoka HC, Tetri BA, Tonascia J, Vuppalanchi R, Yates KP
Studies
Citation
Vuppalanchi R, Deppe RB, Yates KP, Comerford M, Masuoka HC, Tetri BA, Loomba R, Brunt E, Kleiner DE, Tonascia J, Chalasani NP. Changes in Serum Cytokeratin 18 Levels Significantly Predict Changes in Liver Histology in Adults With Nonalcoholic Steatohepatitis: Results From the Pivens Trial. Gastroenterology 2013 May;144(Issue 5, Supplement 1):S-951.

Abstract

Previous cross-sectional studies have shown that serum levels of cytokeratin fragments (CK18) are associated with the presence of steatohepatitis in individuals with nonalcoholic fatty liver disease (NAFLD). However, it is unknown if serial serum CK18 levels can predict longitudinal changes in liver histology in NAFLD.