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Public Release Type:
Journal
Publication Year: 2013
Authors:
Aithal G,
Cordell HJ,
Van Gaal L,
Leathart J,
Liu Y-L,
Tordjman J,
Clement K,
Valenti L,
Day CP,
Daly AK,
Stickel F,
Alison M,
Romero-Gomez M,
Andrade R,
Reeves H,
Bedossa P,
Pihlajamaki J,
Kotronen A,
Yki-Jarvinen H,
Chalasani N,
Kleiner DE,
Rotter J,
Burt A,
Ratziu V,
Anstee QM,
Darlay R
Studies:
Nonalcoholic Steatohepatitis Clinical Research Network
Inter-patient genetic variation and environment determine severity and progression of non-alcoholic fatty liver disease (NAFLD). Previous genome-wide association studies (GWAS) have provided important insights into modifier genes influencing radiologically determined steatosis (Romeo, 2008; Speliotes, 2011) and clinical biochemistry (Chambers, 2011) but have been unable to assess effect on steatohepatitis and fibrosis. Using data drawn form a large GWAS study of patients with histologically characterised NAFLD, we adopted a candidate-gene approach to re-examine the broader validity of these associations.
