Public Release Type:
Journal
Publication Year: 2013
Authors:
Daly AK,
Kleiner DE,
Chalasani N,
Aithal G,
Alison M,
Andrade R,
Anstee QM,
Bedossa P,
Burt A,
Clement K,
Cordell HJ,
Darlay R,
Day CP,
Kotronen A,
Leathart J,
Liu Y-L,
Pihlajamaki J,
Ratziu V,
Reeves H,
Romero-Gomez M,
Rotter J,
Stickel F,
Tordjman J,
Valenti L,
Van Gaal L,
Yki-Jarvinen H
Studies:
Nonalcoholic Steatohepatitis Clinical Research Network
Inter-patient genetic variation and environment determine severity and progression of non-alcoholic fatty liver disease (NAFLD). Previous genome-wide association studies (GWAS) have provided important insights into modifier genes influencing radiologically determined steatosis (Romeo, 2008; Speliotes, 2011) and clinical biochemistry (Chambers, 2011) but have been unable to assess effect on steatohepatitis and fibrosis. Using data drawn form a large GWAS study of patients with histologically characterised NAFLD, we adopted a candidate-gene approach to re-examine the broader validity of these associations.