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Aithal G, Alison M, Andrade R, Anstee QM, Bedossa P, Burt A, Chalasani N, Clement K, Cordell HJ, Daly AK, Darlay R, Day CP, Kleiner DE, Kotronen A, Leathart J, Liu Y-L, Pihlajamaki J, Ratziu V, Reeves H, Romero-Gomez M, Rotter J, Stickel F, Tordjman J, Valenti L, Van Gaal L, Yki-Jarvinen H
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Citation
Anstee QM, Darlay R, Leathart J, Liu Y-L , Tordjman J, Clement K, Aithal G, Valenti L, Van Gaal L, Stickel F, Alison M, Romero-Gomez M, Andrade R, Reeves H, Bedossa P, Pihlajamaki J, Kotronen A, Yki-Jarvinen H, Chalasani N, Kleiner DE, Rotter J, Burt A, Ratziu V, Cordell HJ, Daly AK, Day CP. A candidate-gene approach to validation of genetic modifier associations using a large cohort with histologically characterised nonalcoholic fatty liver disease. J Hepatol 2013 Apr;58(Supplement 1):S46.Abstract
Inter-patient genetic variation and environment determine severity and progression of non-alcoholic fatty liver disease (NAFLD). Previous genome-wide association studies (GWAS) have provided important insights into modifier genes influencing
radiologically determined steatosis (Romeo, 2008; Speliotes, 2011) and clinical biochemistry (Chambers, 2011) but have been unable to assess effect on steatohepatitis and fibrosis. Using data drawn form a large GWAS study of patients with histologically characterised NAFLD, we adopted a candidate-gene approach to re-examine the broader validity of these associations.