PubMed ID:
23336978
Public Release Type:
Journal
Publication Year: 2013
Affiliation: Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
DOI:
https://doi.org/10.1053/j.gastro.2013.01.022
Authors:
Cui S,
Devoto M,
EauClaire SF,
Glessner JT,
Haber BA,
Hakonarson H,
Leyva-Vega M,
Matthews RP,
Spinner NB,
Tsai EA
Studies:
A Prospective Database of Infants With Cholestasis
Biliary atresia (BA) is a progressive fibroinflammatory disorder of infants involving the extrahepatic and intrahepatic biliary tree. Its etiology is unclear but is believed to involve exposure of a genetically susceptible individual to certain environmental factors. BA occurs exclusively in the neonatal liver, so variants of genes expressed during hepatobiliary development could affect susceptibility. Genome-wide association studies previously identified a potential region of interest at 2q37. We continued these studies to narrow the region and identify BA susceptibility genes.